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Information Journal Paper

Title

HISTOCHEMICAL STUDY OF MUCOUS SUBSTANCE OF GASTRIC EPITHELIAL LESIONS

Pages

  65-70

Abstract

 Introduction: MUCINOUS COMPOUNDS are a group of neutral glycoprotein which have a prime effect for protection of surface epithelium against digestion. Studies showed the changes of these compounds in neoplasia and Intestinal metaplasia of the STOMACH. Materials and Methods: Specimens were taken from 25 surgically resected STOMACH from gastric lesion and it's periphery and processed as routine in pahology. Praffin blockes were cutted 3-5m thickness and sections were studied histochemically using Alcian blue pH=1 and pH=2.5, Toluidine blue pH=4.5 in Vernol's buffer,H&E and diffrent blocking techniques such as active metylation, mild metylation and active metylation with Saponification. Results: Results of this study showed the acidic nature of glycoprotein in intestinal metaplasia and signet ring cell CARCINOMA. More ever, sialomucins and sulphomucins were detected in type I and type IIb Intestinal metaplasia. Morever combination of tubidne blue and blocking technique showed that sulphate groups are responsible for metachromasia of MUCINOUS COMPOUNDS. Conclusion: The presence of sulphomucins in intestinl metaplasia recognized as arisk factor for progression of neoplasia , therfore recognition of these compounds inbiopsy specimen is a important warning and needs a serious follow up of the patient.

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    APA: Copy

    ARAB, M.R., ALTIRAIHI, T., & SHARIAT TORBAGHAN, SH.. (2001). HISTOCHEMICAL STUDY OF MUCOUS SUBSTANCE OF GASTRIC EPITHELIAL LESIONS . CELL JOURNAL (YAKHTEH), 3(10), 65-70. SID. https://sid.ir/paper/16191/en

    Vancouver: Copy

    ARAB M.R., ALTIRAIHI T., SHARIAT TORBAGHAN SH.. HISTOCHEMICAL STUDY OF MUCOUS SUBSTANCE OF GASTRIC EPITHELIAL LESIONS . CELL JOURNAL (YAKHTEH)[Internet]. 2001;3(10):65-70. Available from: https://sid.ir/paper/16191/en

    IEEE: Copy

    M.R. ARAB, T. ALTIRAIHI, and SH. SHARIAT TORBAGHAN, “HISTOCHEMICAL STUDY OF MUCOUS SUBSTANCE OF GASTRIC EPITHELIAL LESIONS ,” CELL JOURNAL (YAKHTEH), vol. 3, no. 10, pp. 65–70, 2001, [Online]. Available: https://sid.ir/paper/16191/en

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