CHANGES IN THE GENE EXPRESSION OF
β1 AND 
β2 INTEGRINS FOLLOWING DEVELOPMENT OF TOLERANCE TO ANALGESIC EFFECT OF MORPHINE IN RATS

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GHORBI J.; JAVAN MOHAMMAD; SHEYBANI VAHID

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Title

CHANGES IN THE GENE EXPRESSION OF β1 AND β2 INTEGRINS FOLLOWING DEVELOPMENT OF TOLERANCE TO ANALGESIC EFFECT OF MORPHINE IN RATS

Author(s)

GHORBI J. | JAVAN MOHAMMAD | SHEYBANI VAHID | Issue Writer Certificate

Keywords

MORPHINEQ2

GENE EXPRESSIONQ1

INTEGRINSQ1

MANGANESEQ1

SYNAPTIC PLASTICITYQ3

Abstract

Objective: Considering the inhibitory effect of integrin-activity modulator (manganese) on the development of MORPHINE tolerance; in this study we have tried to assess the effect of chronic administration of both MORPHINE and MANGANESE on the expression levels of b1 and b2 INTEGRINS in the dorsal horn of the lumbar spinal cord.Materials and Methods: MORPHINE tolerance was induced by intrathecal injection of MORPHINE, 15 µg/rat twice a day for five days. In order to study the effect of MANGANESE on tolerance development; we injected MANGANESE alone or in combination with MORPHINE. The analgesic effect of MORPHINE was assessed by using the tail flick test. Semi-quantitative reverse transcription - polymerase chain reaction (RT-PCR) was used to assess the expression levels of b1 and b2 INTEGRINS.Results: As assessed on day 6, five days administration of MORPHINE significantly increased the expression levels of INTEGRINS b1 and b2. Combined administration of MORPHINE and MANGANESE, which inhibited MORPHINE tolerance, prevented the effect of MORPHINE on INTEGRINS’ expression.Conclusion: Increased expression of INTEGRINS may be due to direct effect of chronic MORPHINE or a negative feedback that resulted from the potent inhibitory effect of MORPHINE on INTEGRINS’ activity. It seems that the activating of INTEGRINS via MANGANESE in the presence of MORPHINE can reverse feedback and consequently the effect of chronic administration of MORPHINE on b1 and b2 INTEGRINS’ and expression. Our findings suggest a role for intracellular matrix molecules in the development of MORPHINE tolerance and possibly other forms of SYNAPTIC PLASTICITY.

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APA: Copy

GHORBI, J., JAVAN, MOHAMMAD, & SHEYBANI, VAHID. (2010). CHANGES IN THE GENE EXPRESSION OF β₁ AND β₂ INTEGRINS FOLLOWING DEVELOPMENT OF TOLERANCE TO ANALGESIC EFFECT OF MORPHINE IN RATS. CELL JOURNAL (YAKHTEH), 11(4 (44)), 448-455. SID. https://sid.ir/paper/16222/en

Vancouver: Copy

GHORBI J., JAVAN MOHAMMAD, SHEYBANI VAHID. CHANGES IN THE GENE EXPRESSION OF β₁ AND β₂ INTEGRINS FOLLOWING DEVELOPMENT OF TOLERANCE TO ANALGESIC EFFECT OF MORPHINE IN RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2010;11(4 (44)):448-455. Available from: https://sid.ir/paper/16222/en

IEEE: Copy

J. GHORBI, MOHAMMAD JAVAN, and VAHID SHEYBANI, “CHANGES IN THE GENE EXPRESSION OF β₁ AND β₂ INTEGRINS FOLLOWING DEVELOPMENT OF TOLERANCE TO ANALGESIC EFFECT OF MORPHINE IN RATS,” CELL JOURNAL (YAKHTEH), vol. 11, no. 4 (44), pp. 448–455, 2010, [Online]. Available: https://sid.ir/paper/16222/en

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