The Histological Effects of Diazinon on the Liver and Kidneys of Rats

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Kalvandi Mostafa; Hashemi Seyed Ali; Tavakolifar Bahareh; Bayat Gholamreza; Goudarzvand Mahdi

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Journal Paper

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Journal: PATHOBIOLOGY RESEARCH Year:2025 | Volume:28 | Issue:1 Page(s): 57-63

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Title

The Histological Effects of Diazinon on the Liver and Kidneys of Rats

Author(s)

Keywords

Choronic

Diazinon

histological changes

Liver

Kidney

Abstract

Introduction: Diazinon is an organophosphate pesticide that has widespread applications in both agriculture and household settings. Diazinon poisoning can have detrimental effects on the cardiovascular, gastrointestinal, and central nervous systems. The aim of this study was to investigate the effects of chronic exposure to diazinon on histological features of the liver and kidney of rats. Materials and Methods: Twenty adult male Wistar rats, aged 10 - 12 weeks and weighing 150-200 grams, were purchased and divided into two groups of 10. In the treatment group, diazinon was administered at a dose of 20 mg/kg/day to each animal for 3 months, while the control group was maintained on a normal diet and drinking water. After 12 weeks of exposure, the animals were prepared for H & E staining, and the samples were examined under a light microscope. Findings: The structural integrity of the liver and kidney was preserved in the diazinon-treated group compared to the control group, but mild effects of diazinon were observed in the liver tissue, such as foci of inflammation and hyperplasia of Kupffer cells, and in the kidney, such as the presence of epithelial cells in the distal tubule and cell detachment from the basement membrane. Conclusion: Based on the results of this study, the rats exposed to diazinon did not show significant changes in histological features in the liver and kidney, and these changes were subtle, possibly indicating a need for higher doses or longer exposure durations to diazinon.

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