EVALUATION OF BAX ENCODING PLASMID FOR INCREASING EFFICACY OF DNA VACCINE PLASMID ENCODING GB OF HERPES SIMPLEX VIRUS TYPE 1

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PARSANIA MASOUD; MOHAMMAD HASAN ZOHEYR; BAMDAD T.; KHEYR ANDISH MARYAM; SAR BOLOUKI M.N.; POURIAYE VALI M.H.; DOROST KAR SARI R.A.; MAHDAVI MAHDI; JAMALI ABAS

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Journal: Cell Journal (Yakhteh) Year:2008 | Volume:10 | Issue:2 (38) Page(s): 93-100

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Title

EVALUATION OF BAX ENCODING PLASMID FOR INCREASING EFFICACY OF DNA VACCINE PLASMID ENCODING GB OF HERPES SIMPLEX VIRUS TYPE 1

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BAX PROTEINQ1

DNA VACCINEQ1

GB PROTEIN OF HERPES SIMPLEX VIRUS-1Q1

Abstract

Objective: Evaluation of Bax encoding plasmid for increasing efficacy of DNA VACCINE plasmid encoding gB of Herpes Simplex Virus type 1.Materials and Methods: We compared three different dosages of Bax encoding plasmid (pcbax) including 10, 25 and 50 mg of plasmid DNA. They were co-injected ineradermally with glycoprotein B (gB) of herpes simplex virus (HSV)-1 encoded plasmid (pcgB) in C57BL/6 mice to elicit immune responses to protect against lethal HSV-1 challenge. Immune responses to the antigen were assessed by lymphocyte proliferative responses and cytokine (INF-g and IL-4) release assays.Results: The study demonstrates that the mice immunized with 25 mg pcbax together with pcgB have more efficient protection than the mice immunized with 10 and 50 mg of pcbax and pcgB. Analysing of cell-mediated responses show that the mice immunized with 25mg pcbax and pcgB induce stronger lymphocyte proliferative responses and higher levels of INF-g and IL-4 compared to the mice are received 10 and 50 mg of pcbax and pcgB.Conclusion: The data show that co-immunization with 25 mg of pcbax and pcgB increase immune responses compared to 10 and 50 mg of pcbax and pcgB. This can be considered a promising approach for development an efficient DNA VACCINE against HSV-1 or other pathogens.

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APA: Copy

PARSANIA, MASOUD, MOHAMMAD HASAN, ZOHEYR, BAMDAD, T., KHEYR ANDISH, MARYAM, SAR BOLOUKI, M.N., POURIAYE VALI, M.H., DOROST KAR SARI, R.A., MAHDAVI, MAHDI, & JAMALI, ABAS. (2008). EVALUATION OF BAX ENCODING PLASMID FOR INCREASING EFFICACY OF DNA VACCINE PLASMID ENCODING GB OF HERPES SIMPLEX VIRUS TYPE 1. CELL JOURNAL (YAKHTEH), 10(2 (38)), 93-100. SID. https://sid.ir/paper/16326/en

Vancouver: Copy

PARSANIA MASOUD, MOHAMMAD HASAN ZOHEYR, BAMDAD T., KHEYR ANDISH MARYAM, SAR BOLOUKI M.N., POURIAYE VALI M.H., DOROST KAR SARI R.A., MAHDAVI MAHDI, JAMALI ABAS. EVALUATION OF BAX ENCODING PLASMID FOR INCREASING EFFICACY OF DNA VACCINE PLASMID ENCODING GB OF HERPES SIMPLEX VIRUS TYPE 1. CELL JOURNAL (YAKHTEH)[Internet]. 2008;10(2 (38)):93-100. Available from: https://sid.ir/paper/16326/en

IEEE: Copy

MASOUD PARSANIA, ZOHEYR MOHAMMAD HASAN, T. BAMDAD, MARYAM KHEYR ANDISH, M.N. SAR BOLOUKI, M.H. POURIAYE VALI, R.A. DOROST KAR SARI, MAHDI MAHDAVI, and ABAS JAMALI, “EVALUATION OF BAX ENCODING PLASMID FOR INCREASING EFFICACY OF DNA VACCINE PLASMID ENCODING GB OF HERPES SIMPLEX VIRUS TYPE 1,” CELL JOURNAL (YAKHTEH), vol. 10, no. 2 (38), pp. 93–100, 2008, [Online]. Available: https://sid.ir/paper/16326/en

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