HISTOCHEMICAL STUDY OF N-ACETYLGALACTOSAMINE CONTAINING GLYCOCONJUGATE IN INTRADUCTAL CARCINOMA OF THE BREAST BY HPA LECTIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ARAB M.R.; SEPEHRI Z.; IMANI H.; KARIMI MEHRBOD; SARGOLZAEI AVAL F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2006 | Volume:7 | Issue:4 (28) Page(s): 216-221

Download Full-Text

Persian Verion

View:

1,127

Download:

250

Cites:

Information Journal Paper

Title

HISTOCHEMICAL STUDY OF N-ACETYLGALACTOSAMINE CONTAINING GLYCOCONJUGATE IN INTRADUCTAL CARCINOMA OF THE BREAST BY HPA LECTIN

Author(s)

Keywords

BREASTQ2

INTRADUCTAL CARCINOMAQ2

GLYCOCONJUGATEQ3

LECTINQ3

Abstract

Introduction: GLYCOCONJUGATEs are a class of glycoproteins or glycolipids, their terminal sugars are responsible for cell-cell and/or cell-extracellular matrix interactions. Aberrant glycosylation of these compounds are one of the most important aspects of cellular transformation, metastasis and escape of tumoral cells from immune system and resistance to antineoplastic drugs. Recent studies showed that patients with HPA (helix pomatia agglutinin) positive INTRADUCTAL CARCINOMA cells have worse prognosis compared to patients with HPA negative cells. The aim of the present study was to define the presence of GalNac terminal sugar in GLYCOCONJUGATE of different grades of intraductal BREAST carcinoma and to compare the degree and the pattern of reactivity of tumoral cells to HPA LECTIN. Materials and Methods: The paraffin blocks belonging to 20 patients of INTRADUCTAL CARCINOMA was chosen from pathology archive of Khatam-Al-Anbia hospital in Zahedan and 5-7 micrometer sections were prepared. Two expert pathologists determined histopathological grading independently. The LECTIN histochemistry was performed using HPA. The same observers determined histochemical grading. Data were analyzed by NPAR (non-parametric) test of Mann Whitney. Results: Results of this study revealed that the pattern and the degree of histochemical reactivity of neoplastic cells differ in all grades of INTRADUCTAL CARCINOMA. Histochemical staining showed significant difference between grades of INTRADUCTAL CARCINOMA of the BREAST (p<0.003). The lowest reactivity was seen in grade I and the highest in grade III. Furthermore, the reaction of tumoral cells was primarily confined to apical surfaces of cells in grade I, to the Golgi zone in grade II, and to a diffuse cytoplasmic distribution in grade III. Conclusion: Our data suggest that the HPA reactivity of tumoral cells were different in all grades of INTRADUCTAL CARCINOMA. The tumor cells showed aberrant glycosylation, which occurred in the course of anaplastic changes. It seems that our data suggest a potential and clinically important role of HPA reactivity to predict the invasive nature of malignant tumoral cells of INTRADUCTAL CARCINOMA of the BREAST.

Cites

No record.

References

Cite

APA: Copy

ARAB, M.R., SEPEHRI, Z., IMANI, H., KARIMI, MEHRBOD, & SARGOLZAEI AVAL, F.. (2006). HISTOCHEMICAL STUDY OF N-ACETYLGALACTOSAMINE CONTAINING GLYCOCONJUGATE IN INTRADUCTAL CARCINOMA OF THE BREAST BY HPA LECTIN. CELL JOURNAL (YAKHTEH), 7(4 (28)), 216-221. SID. https://sid.ir/paper/16369/en

Vancouver: Copy

ARAB M.R., SEPEHRI Z., IMANI H., KARIMI MEHRBOD, SARGOLZAEI AVAL F.. HISTOCHEMICAL STUDY OF N-ACETYLGALACTOSAMINE CONTAINING GLYCOCONJUGATE IN INTRADUCTAL CARCINOMA OF THE BREAST BY HPA LECTIN. CELL JOURNAL (YAKHTEH)[Internet]. 2006;7(4 (28)):216-221. Available from: https://sid.ir/paper/16369/en

IEEE: Copy

M.R. ARAB, Z. SEPEHRI, H. IMANI, MEHRBOD KARIMI, and F. SARGOLZAEI AVAL, “HISTOCHEMICAL STUDY OF N-ACETYLGALACTOSAMINE CONTAINING GLYCOCONJUGATE IN INTRADUCTAL CARCINOMA OF THE BREAST BY HPA LECTIN,” CELL JOURNAL (YAKHTEH), vol. 7, no. 4 (28), pp. 216–221, 2006, [Online]. Available: https://sid.ir/paper/16369/en

Related Journal Papers