TISSUE REGENERATION THROUGH SELF-ASSEMBLED PEPTIDE AMPHIPHILE NANOFIBERS

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HOSSEINKHANI H.; HOSSEIN KHANI M.; KHADEM HOSSEINI A.

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Journal: Cell Journal (Yakhteh) Year:2006 | Volume:8 | Issue:3 (31) Page(s): 204-209

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Title

TISSUE REGENERATION THROUGH SELF-ASSEMBLED PEPTIDE AMPHIPHILE NANOFIBERS

Author(s)

HOSSEINKHANI H. | HOSSEIN KHANI M. | KHADEM HOSSEINI A. | Issue Writer Certificate

Keywords

TISSUE REGENERATIONQ2

CONTROLLED RELEASEQ2

GROWTH FACTORQ2

Abstract

Introduction: In the present study, we hypothesized that a novel approach to promote vascularization would be to create injectable three dimensional (3-D) scaffolds within GROWTH FACTOR that enhance the sustained release of GROWTH FACTOR and induce the angiogenesis.Material and Methods: We demonstrate that a 3-D scaffold can be formed by mixing of peptide-amphiphile (PA) aqueous solution with hepatocyte GROWTH FACTOR (HGF) solution. PA was synthesized by standard solid phase chemistry that ends with the alkylation of the NH2 terminus of the peptide. The sequence of arginine-glycineaspartic acid (RGD) was included in peptide design as well. A 3-D network of nanofibers was formed by mixing HGF suspensions with dilute aqueous solution of PA.Results: Scanning electron microscopy (SEM) examination revealed the formation of fibrous assemblies with an extremely high aspect ratio and high surface areas with mean diameter of less than 200 nm. In vitro HGF release profile of 3-D nanofibers was investigated while angiogenesis induced by the released HGF was being assessed. In vivo potential ability of PA nanofibers to induce angiogenesis was assessed through subcutaneous injection of PA solution, HGF solution, and PA in combination with HGF solutions. Injection of PA with HGF induced significant angiogenesis around the injected site, in marked contrast to HGF injection alone and PA injection alone.Conclusion: The combination of HGF-induced angiogenesis is a promising procedure to improve TISSUE REGENERATION.

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APA: Copy

HOSSEINKHANI, H., HOSSEIN KHANI, M., & KHADEM HOSSEINI, A.. (2006). TISSUE REGENERATION THROUGH SELF-ASSEMBLED PEPTIDE AMPHIPHILE NANOFIBERS. CELL JOURNAL (YAKHTEH), 8(3 (31)), 204-209. SID. https://sid.ir/paper/16504/en

Vancouver: Copy

HOSSEINKHANI H., HOSSEIN KHANI M., KHADEM HOSSEINI A.. TISSUE REGENERATION THROUGH SELF-ASSEMBLED PEPTIDE AMPHIPHILE NANOFIBERS. CELL JOURNAL (YAKHTEH)[Internet]. 2006;8(3 (31)):204-209. Available from: https://sid.ir/paper/16504/en

IEEE: Copy

H. HOSSEINKHANI, M. HOSSEIN KHANI, and A. KHADEM HOSSEINI, “TISSUE REGENERATION THROUGH SELF-ASSEMBLED PEPTIDE AMPHIPHILE NANOFIBERS,” CELL JOURNAL (YAKHTEH), vol. 8, no. 3 (31), pp. 204–209, 2006, [Online]. Available: https://sid.ir/paper/16504/en

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