مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Antihypertensive Potential of Euphorbia hirta and Leptadenia hastata in Adrenaline-induced Wistar Rats

Author(s)

 Bushirat Oyenike Fagbohun Bushirat Oyenike Fagbohun | Ochonung Emmanuel Ogar Ochonung Emmanuel Ogar | Atapia Innocent Messiah Atapia Innocent Messiah | Hassan Abdulsalam Adewuyi Hassan Abdulsalam Adewuyi | Waheed Sakariyau Adio Waheed Sakariyau Adio | Adebimpe Hameedah Oluwatoyin Adebimpe Hameedah Oluwatoyin | Chizoba Victory Obunadike Chizoba Victory Obunadike | Adeleye Adegboyega Edema Adeleye Adegboyega Edema | Samad Hussein Samad Hussein | Usman Abiola Mohammed Usman Abiola Mohammed | Tolulope Olukayode Jaiyeola Tolulope Olukayode Jaiyeola | Issue Writer Certificate 

Pages

  139-146

Abstract

 Background: Hypertension is a major public health concern worldwide, contributing to cardiovascular morbidity and mortality. The use of plant-based therapies, such as Euphorbia hirta and Leptadenia hastata, has gained attention for their potential antioxidant, anti-hyperlipidemic, and organ-protective effects.  Objectives: This study aimed to investigate the phytotherapeutic approach to hypertension using E. hirta and L. hastata extracts in adrenaline-induced hypertensive Wistar rats Methods: Utilizing an adrenaline-induced hypertensive rat model, we assessed the effects of E. hirta and L. hastata leaf extracts (50, 100, and 200 mg/kg) on systolic blood pressure, renal function, lipid metabolism, and hematological parameters. Results: Antioxidant activity: Increased levels of superoxide dismutase, catalase, and glutathione peroxidase. Lipid profiles: Reduced levels of total cholesterol, triglycerides, and LDL cholesterol. Liver function tests (LFTs): Decreased levels of alanine transaminase and aspartate transaminase. Hematological parameters: Improved red blood cell count, hemoglobin, and packed cell volume (PCV). Conclusion: This preclinical investigation provides compelling evidence for the antihypertensive potential of E. hirta and L. hastata leaf extracts, validating their traditional use. These findings underscore the promise of these natural products as adjunctive therapeutics for hypertension management, warranting further clinical investigation.

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