EFFECT OF LISTERIA MONOCYTOGENES ON TUMOR IMMUNOTHERAPY WITH DENDRITIC CELLS

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MOTAMEDI MASOUMEH; ARAB S.; KHANSARI NEMAT ELAH; MOAZENI S.M.; VOJGANI MOHAMMAD; KEYHANI A.A.H.; GHEFLATI ZAHRA; ABOUFAZELI T.; HAJATI JAMSHID

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Journal: Cell Journal (Yakhteh) Year:2007 | Volume:8 | Issue:4 (32) Page(s): 252-257

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Title

EFFECT OF LISTERIA MONOCYTOGENES ON TUMOR IMMUNOTHERAPY WITH DENDRITIC CELLS

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Keywords

LISTERIA MONOCYTOGENESQ2

CANCER IMMUNOTHERAPYQ2

IL-12Q2

DENDERITIC CELLQ2

Abstract

Introduction: Different microbial compounds can induce maturation of dendritic cells (DCs) into DC1 or DC2 .In the present study, we used tumor antigen pulsed dendritic cell that matured with LISTERIA MONOCYTOGENES antigen and cholera toxin (CT) in the treatment of a murin model of cancer.Material and Methods: Tumor cells (WEHI-164 BALB/C derived fibrosarsoma) were injected subcutaneously to Balb/c mice. Bone marrow cells were cultured with GM-CSF and IL-4.On day 5, Listeria monocytogen lysate or CT (cholera toxin) added to culture for 2 days.For immunization, 106 dendritic cells matured with CT or LISTERIA MONOCYTOGENES (L.m injected) subcutaneously around the tumor site.Results: We found that Immunotherapy with dendritic cells treated with listeria antigens leads to delay in tumor growth as compared to the CT and control groups. DCs treated with Listeria produce higher amount of IL-12 compare to CT and control groups.Conclusion: Some microbial components such as LISTERIA MONOCYTOGENES that favors the immune response towards TH1 could be used in generating powerful DCs for CANCER IMMUNOTHERAPY.

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APA: Copy

MOTAMEDI, MASOUMEH, ARAB, S., KHANSARI, NEMAT ELAH, MOAZENI, S.M., VOJGANI, MOHAMMAD, KEYHANI, A.A.H., GHEFLATI, ZAHRA, ABOUFAZELI, T., & HAJATI, JAMSHID. (2007). EFFECT OF LISTERIA MONOCYTOGENES ON TUMOR IMMUNOTHERAPY WITH DENDRITIC CELLS. CELL JOURNAL (YAKHTEH), 8(4 (32)), 252-257. SID. https://sid.ir/paper/16531/en

Vancouver: Copy

MOTAMEDI MASOUMEH, ARAB S., KHANSARI NEMAT ELAH, MOAZENI S.M., VOJGANI MOHAMMAD, KEYHANI A.A.H., GHEFLATI ZAHRA, ABOUFAZELI T., HAJATI JAMSHID. EFFECT OF LISTERIA MONOCYTOGENES ON TUMOR IMMUNOTHERAPY WITH DENDRITIC CELLS. CELL JOURNAL (YAKHTEH)[Internet]. 2007;8(4 (32)):252-257. Available from: https://sid.ir/paper/16531/en

IEEE: Copy

MASOUMEH MOTAMEDI, S. ARAB, NEMAT ELAH KHANSARI, S.M. MOAZENI, MOHAMMAD VOJGANI, A.A.H. KEYHANI, ZAHRA GHEFLATI, T. ABOUFAZELI, and JAMSHID HAJATI, “EFFECT OF LISTERIA MONOCYTOGENES ON TUMOR IMMUNOTHERAPY WITH DENDRITIC CELLS,” CELL JOURNAL (YAKHTEH), vol. 8, no. 4 (32), pp. 252–257, 2007, [Online]. Available: https://sid.ir/paper/16531/en

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