ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC LEAF EXTRACT OF HEDERA HELIX IN MALE RAT

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MAHMOUDI M.; MOHAMMADI S.; SHAHIDI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Avicenna Journal of Clinical Medicine Year:2013 | Volume:20 | Issue:2 (SN 68) Page(s): 119-125

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Title

ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC LEAF EXTRACT OF HEDERA HELIX IN MALE RAT

Author(s)

MAHMOUDI M. | MOHAMMADI S. | SHAHIDI S. | Issue Writer Certificate

Keywords

HEDERA HELIXQ2

PAINQ2

PLANTSQ2

MEDICINALQ3

RATSQ3

Abstract

Introduction & Objective: The consumption of chemical compounds and MEDICINAL herbs are different ways to control PAIN. On the other hand, the complications of chemical drugs and their expensiveness cause people to use herbal medicines The aim of this study was to investigate the antinociceptive effect of hydroalcoholic leaf extract of HEDERA HELIX in male RATS.Materials & Methods: In this experimental study, 36 adult male RATS were divided into 6 groups: control, morphine (1mg/kg), HEDERA HELIX extract (100, 200, 300mg/kg, i.p.) and naloxone (1mg/kg) with HEDERA HELIX extract (200 mg/kg). The analgesic effects of HEDERA HELIX extract were assessed with writhing and tail flick tests.Results: The results of this study showed that doses of 200 and 300mg/kg of HEDERA HELIX extract decreased PAIN significantly. However, dose of 300mg/kg of HEDERA HELIX extract showed more antinociceptive effect of HEDERA HELIX extract. The naloxone and HEDERA HELIX extract combination increased the number of writhing compared with the HEDERA HELIX extract group.Conclusion: In this study analgesic effect of the hydroalcoholic extract of HEDERA HELIX was observed. The antinociceptive effect of extract was probably occurred by activation of opioid system.

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APA: Copy

MAHMOUDI, M., MOHAMMADI, S., & SHAHIDI, S.. (2013). ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC LEAF EXTRACT OF HEDERA HELIX IN MALE RAT. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 20(2 (SN 68)), 119-125. SID. https://sid.ir/paper/17482/en

Vancouver: Copy

MAHMOUDI M., MOHAMMADI S., SHAHIDI S.. ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC LEAF EXTRACT OF HEDERA HELIX IN MALE RAT. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2013;20(2 (SN 68)):119-125. Available from: https://sid.ir/paper/17482/en

IEEE: Copy

M. MAHMOUDI, S. MOHAMMADI, and S. SHAHIDI, “ANTINOCICEPTIVE EFFECT OF HYDROALCOHOLIC LEAF EXTRACT OF HEDERA HELIX IN MALE RAT,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 20, no. 2 (SN 68), pp. 119–125, 2013, [Online]. Available: https://sid.ir/paper/17482/en

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