PROTECTIVE EFFECT OF CAPSICUM FRUTESCENS ON CONTRACTILE REACTIVITY OF STREPTOZOTOCIN- DIABETIC RATS

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ROUGHANI DEHKORDI F.; ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT

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Journal: Avicenna Journal of Clinical Medicine Year:2005 | Volume:12 | Issue:2 (SN 36) Page(s): 5-9

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Title

PROTECTIVE EFFECT OF CAPSICUM FRUTESCENS ON CONTRACTILE REACTIVITY OF STREPTOZOTOCIN- DIABETIC RATS

Author(s)

ROUGHANI DEHKORDI F. | ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | Issue Writer Certificate

Keywords

PEPPERQ3

REDQ3

CARDIOVASCULAR SYSTEMQ3

DIABETES MELLITUS CONTRACTILE RESPONSEQ3

RATSQ3

Abstract

Introduction & Objective: Considering the higher incidence of atherosclerosis and cardiovascular disorders in diabetes mellitus, this study was conducted to evaluate the effect of oral one-month administration of RED PEPPER (Capsicum frutescens) on the contractile reactivity of isolated aorta in diabetic RATS. Materials & Methods: For this purpose, male Wistar RATS (n=32) were randomly divided into control, PEPPER-treated control, diabetic, and PEPPER-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered (60 mg/Kg). PEPPER-treated groups received PEPPER mixed with standard pelleted food at a weight ratio of 1/15. After one month, contractile reactivity of aortic rings to KCI and noreadrenaline was determined using isolated tissue setup.Results: Serum glucose level showed a significant increase in diabetic group at 2nd and 4th weeks (P<0.001), while this increase was less marked in PEPPER-treated diabetic group at the 2nd.week (P<0.05). In addition, the latter group showed a lower contraction to KCl (P<0.05) and noreadrenaline (P<0.05) as compared to diabetic group. Meanwhile, there was no significant difference between control and PEPPER-treated control groups regarding contractile reactivity.Conclusion: It can be concluded that oral administration of PEPPER for one month could attenuate the contractile responsiveness of the vascular system and may prevent the development of hypertension in diabetic RATS.

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APA: Copy

ROUGHANI DEHKORDI, F., ROUGHANI, M., & BALUCHNEJADMOJARAD, TOURANDOKHT. (2005). PROTECTIVE EFFECT OF CAPSICUM FRUTESCENS ON CONTRACTILE REACTIVITY OF STREPTOZOTOCIN- DIABETIC RATS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 12(2 (SN 36)), 5-9. SID. https://sid.ir/paper/17660/en

Vancouver: Copy

ROUGHANI DEHKORDI F., ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT. PROTECTIVE EFFECT OF CAPSICUM FRUTESCENS ON CONTRACTILE REACTIVITY OF STREPTOZOTOCIN- DIABETIC RATS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2005;12(2 (SN 36)):5-9. Available from: https://sid.ir/paper/17660/en

IEEE: Copy

F. ROUGHANI DEHKORDI, M. ROUGHANI, and TOURANDOKHT BALUCHNEJADMOJARAD, “PROTECTIVE EFFECT OF CAPSICUM FRUTESCENS ON CONTRACTILE REACTIVITY OF STREPTOZOTOCIN- DIABETIC RATS,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 12, no. 2 (SN 36), pp. 5–9, 2005, [Online]. Available: https://sid.ir/paper/17660/en

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