THE EFFECTS OF CHITOSAN/POLYVINILALCHOL NANOFIBERS SCAFFOLD ON SKIN BURNS IN ADULT MALE NMRI MOUSE

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RIAHI L.; HAYATI ROODBARI N.; SALAHSHOOR KORDESTANI SOHEILA; PARIVAR K.

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2015 | Volume:8 | Issue:1 Page(s): 25-36

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Title

THE EFFECTS OF CHITOSAN/POLYVINILALCHOL NANOFIBERS SCAFFOLD ON SKIN BURNS IN ADULT MALE NMRI MOUSE

Author(s)

RIAHI L. | HAYATI ROODBARI N. | SALAHSHOOR KORDESTANI SOHEILA | PARIVAR K. | Issue Writer Certificate

Keywords

CHITOSANQ2

POLYVINYLALCOHOLQ1

ELECTROSPINNINGQ2

NANOFIBROUS SCAFFOLDSQ2

WOUND HEALINGQ2

Abstract

To repair the wounds of burns a wide range of research including the use of bio-scaffolds due to ability to achieve the desired characteristics has been done. According to favorable biological properties of CHITOSAN such as biocompatibility, antimicrobial properties and the ability to improve WOUND HEALING in biomedical applications, and also due to biocompatibility and lack of stimulation of the immune system of polyvinyl alcohol, the authors decided to investigate the in-vivo effect of Nanofiber scaffolds on the mix of these two polymers on damaged skin. 30 NMRI male mice were randomly divided in to a control group and three experimental groups (Scaffolding CHITOSAN: POLYVINYLALCOHOL ratio of 0.100, 20.80, 30.70). Under sterile conditions and anesthesia, a 1 cm in diameter and full thickness skin wounds was created on the back of each mouse. ELECTROSPINNING nanofiber scaffolds were applied as wound dressing to cover the burn. The burn area was sterile every day and scaffolding was dressing on the wound. After 21 days histological studies have been done on the wound. The results showed a significant meaningful reduction in wound diameter in the experimental group in comparison to control group (p<0.001) and increasing in the thickness of epidermis, dermis and hypodermis compared to controls (p<0.05). Pathology results showed the desired effect of nanofiber scaffolds combined with CHITOSAN/polyvinyl alcohol compared to control group. Also increase in the rate of wound shrinkage has been seen in samples containing scaffolds compared to control samples.

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APA: Copy

RIAHI, L., HAYATI ROODBARI, N., SALAHSHOOR KORDESTANI, SOHEILA, & PARIVAR, K.. (2015). THE EFFECTS OF CHITOSAN/POLYVINILALCHOL NANOFIBERS SCAFFOLD ON SKIN BURNS IN ADULT MALE NMRI MOUSE. JOURNAL OF ANIMAL BIOLOGY, 8(1), 25-36. SID. https://sid.ir/paper/176699/en

Vancouver: Copy

RIAHI L., HAYATI ROODBARI N., SALAHSHOOR KORDESTANI SOHEILA, PARIVAR K.. THE EFFECTS OF CHITOSAN/POLYVINILALCHOL NANOFIBERS SCAFFOLD ON SKIN BURNS IN ADULT MALE NMRI MOUSE. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2015;8(1):25-36. Available from: https://sid.ir/paper/176699/en

IEEE: Copy

L. RIAHI, N. HAYATI ROODBARI, SOHEILA SALAHSHOOR KORDESTANI, and K. PARIVAR, “THE EFFECTS OF CHITOSAN/POLYVINILALCHOL NANOFIBERS SCAFFOLD ON SKIN BURNS IN ADULT MALE NMRI MOUSE,” JOURNAL OF ANIMAL BIOLOGY, vol. 8, no. 1, pp. 25–36, 2015, [Online]. Available: https://sid.ir/paper/176699/en

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