THE EFFECT OF GRAPE SEED EXTRACT ON LIPID PEROXIDATION DUO TO ISCHEMIA/HYPOPERFUSION IN MALE RAT STRIATUM

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RAFIEI RAD M.; SARKAKI A.; HOSEINI E.; FARBOOD Y.; MANSOURI S.M.T.; MOTAMEDI F.

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2011 | Volume:3 | Issue:4 Page(s): 37-44

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Title

THE EFFECT OF GRAPE SEED EXTRACT ON LIPID PEROXIDATION DUO TO ISCHEMIA/HYPOPERFUSION IN MALE RAT STRIATUM

Author(s)

Keywords

CEREBRAL ISCHEMIAQ2

GSEQ2

LPOQ2

STRIATUMQ2

Abstract

CEREBRAL ISCHEMIA leads to neuronal death invulnerable sections of brain that is due to free radical production and oxidative damage. This study aimed to evaluate the effect of 28 days oral administration of grape seed extract (GSE) (100 mg/pkg (on brain oxidative stress indices after permanent bilateral common carotid arteries occlusion (2VO) or ischemia/hypo perfusion in male adult rats. Materials and methods: a number of 30 rats were divided into test and control groups. To make animal model of permanent cerebral hypo perfusion/ischemia, carotid arteries were ligatured upper and lower and cut bilaterally. Rat brain tissue to separate STRIATUM and measurement of malondialdehyde were extracted. Results: results showed that chronic two-vessel occlusion (2VO) hypo perfusion-ischemia increases brain oxidants such as lipid per oxidation (LPO) (p<0.001. (Post ischemic GSE treatment significantly reduced LPO in STRIATUM) p<0.001 (. Conclusion: GSE administration could remove or scavenge oxidants from brain tissue and improve its function and possibly be used as a way to treat this disease.

Cites

EFFECT OF GALLIC ACID ON PASSIVE AVOIDANCE MEMORY UNDER BRAIN ISCHEMIA CONDITIONS IN MATURE FEMALE RATS

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APA: Copy

RAFIEI RAD, M., SARKAKI, A., HOSEINI, E., FARBOOD, Y., MANSOURI, S.M.T., & MOTAMEDI, F.. (2011). THE EFFECT OF GRAPE SEED EXTRACT ON LIPID PEROXIDATION DUO TO ISCHEMIA/HYPOPERFUSION IN MALE RAT STRIATUM. JOURNAL OF ANIMAL BIOLOGY, 3(4), 37-44. SID. https://sid.ir/paper/176804/en

Vancouver: Copy

RAFIEI RAD M., SARKAKI A., HOSEINI E., FARBOOD Y., MANSOURI S.M.T., MOTAMEDI F.. THE EFFECT OF GRAPE SEED EXTRACT ON LIPID PEROXIDATION DUO TO ISCHEMIA/HYPOPERFUSION IN MALE RAT STRIATUM. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2011;3(4):37-44. Available from: https://sid.ir/paper/176804/en

IEEE: Copy

M. RAFIEI RAD, A. SARKAKI, E. HOSEINI, Y. FARBOOD, S.M.T. MANSOURI, and F. MOTAMEDI, “THE EFFECT OF GRAPE SEED EXTRACT ON LIPID PEROXIDATION DUO TO ISCHEMIA/HYPOPERFUSION IN MALE RAT STRIATUM,” JOURNAL OF ANIMAL BIOLOGY, vol. 3, no. 4, pp. 37–44, 2011, [Online]. Available: https://sid.ir/paper/176804/en

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