The Effect of Hydroalcoholic Extract Internal Layer of Iranian Oak (Quercus persica) on the Process of Wound Healing and Collagen Synthesis in Wistar Rats

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Kakoie Azadeh; KARIMI AKBAR; Toghiani Shima

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2019 | Volume:12 | Issue:1 Page(s): 49-56

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Title

The Effect of Hydroalcoholic Extract Internal Layer of Iranian Oak (Quercus persica) on the Process of Wound Healing and Collagen Synthesis in Wistar Rats

Author(s)

Kakoie Azadeh | KARIMI AKBAR | Toghiani Shima | Issue Writer Certificate

Keywords

Quercus persicaQ2

wound healingQ2

collagen synthesisQ1

RatQ2

Abstract

Due to their lower complications than chemical compounds, herbal medicines have received attention from doctors. In this study, Internal Layer of Persian Oak (Quercus persica), which is used in traditional medicine for chronic dermatologic disorders and eczema, was utilized to investigate cutaneous ulcer healing. Thirty adult male Wistar Rats in 5 groups were treated while kept under normal laboRatory conditions by creating a wound with dimensions of 1. 5 × 1. 5 cm2 and a depth of 2 mm in the back. The control group, the sham group, and the experimental groups consist of hydro-alcoholic extract of Internal Layer of Quercus persica at a dose of 250 mg / kg, hydro-alcoholic extract of Quercus persica at a dose of 500 mg / kg, and hydro-alcoholic extract of Quercus persica extract at a dose of 1000 mg / kg, respectively. Topical treatment of ulcers was performed in a 10-day interval every other day, and on the 6th, 8th and 10th days, tissue samples were prepared from the scars. After samples were washed, they were fixed in 10% formalin and hematoxylin-eosin staining of samples, epidermal thickness, wound healing percent, and collagen density were assessed and data were analyzed using SPSS software. In the experimental groups, there was a significant increase (at the level of p < 0. 05 and p < 0. 01) in the epidermal thickness and the wound healing percent, indicating the significant effect of Internal Layer of Iranian oak Jaft extract on the wound reconstruction, but no significant effect was observed on collagenization in this study Internal Layer of Iranian oak hydroalcoholic extract may have an effective role in acceleRating skin wounds healing.

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APA: Copy

Kakoie, Azadeh, KARIMI, AKBAR, & Toghiani, Shima. (2019). The Effect of Hydroalcoholic Extract Internal Layer of Iranian Oak (Quercus persica) on the Process of Wound Healing and Collagen Synthesis in Wistar Rats. JOURNAL OF ANIMAL BIOLOGY, 12(1 ), 49-56. SID. https://sid.ir/paper/176858/en

Vancouver: Copy

Kakoie Azadeh, KARIMI AKBAR, Toghiani Shima. The Effect of Hydroalcoholic Extract Internal Layer of Iranian Oak (Quercus persica) on the Process of Wound Healing and Collagen Synthesis in Wistar Rats. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2019;12(1 ):49-56. Available from: https://sid.ir/paper/176858/en

IEEE: Copy

Azadeh Kakoie, AKBAR KARIMI, and Shima Toghiani, “The Effect of Hydroalcoholic Extract Internal Layer of Iranian Oak (Quercus persica) on the Process of Wound Healing and Collagen Synthesis in Wistar Rats,” JOURNAL OF ANIMAL BIOLOGY, vol. 12, no. 1 , pp. 49–56, 2019, [Online]. Available: https://sid.ir/paper/176858/en

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