DETERMINATION OF SEIZURE THRESHOLD DUE TO INTRAPRITONEAL INJECTION OF HARMALINE IN NMRI MICE

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VAEZI GH.H.; TORABI M.; SHIRAVI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2010 | Volume:2 | Issue:3 Page(s): 43-50

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Title

DETERMINATION OF SEIZURE THRESHOLD DUE TO INTRAPRITONEAL INJECTION OF HARMALINE IN NMRI MICE

Author(s)

VAEZI GH.H. | TORABI M. | SHIRAVI A. | Issue Writer Certificate

Keywords

HARMALINEQ3

MICEQ2

SEIZURE THRESHOLDQ3

BETA CARBOLINEQ3

PEGANUM HARMALAQ3

ALKALOIDSQ3

PTZQ3

Abstract

HARMALINE is one of the ALKALOIDS that exist in different plant like PEGANUM HARMALA. This alkaloid has stimulative effect on releasing serotonin and Catecholamines in different parts of the brain. Also this alkaloid has hallucinogenic effect. One of the most important pharmacological effects of HARMALINE is the inhibitory effect on Monoamine oxidase enzyme. Also HARMALINE with attachment to Inverse agonist locus GABA-A receptors produced a wide range of antagonistic effects against benzodiazepins and interference of benzodiazepine receptors in produce seizure and tremor has show. This research has done to estimate SEIZURE THRESHOLD due to intrapritoneal injection of HARMALINE in comparison with SEIZURE THRESHOLD pentylenetetrazole (PTZ) of male NMRI MICE. In this research the positive control receive of amount 45mg/kg, ip of PTZ and the other groups were injected with 5, 10, 20 mg/kg, ip of HARMALINE. After above injections, seizure symptom has been estimated. As result of this research indicate the SEIZURE THRESHOLD in positive group (PTZ) is amount 45mg/kg and SEIZURE THRESHOLD of HARMALINE is amount 5 mg/kg. In conclusion can reveal that HARMALINE with attachment to Inverse agonist locus GABA-A receptors produced a wide range of antagonistic effects against benzodiazepins and has showed that gabaergic system and serotonin neurotransmitters are involved in seizure activity due to HARMALINE, while in seizure due to PTZ, interfere picrotoxine locus of GABA receptor and benzodiazepine locus has partial role on its effects.The result of this research has been shown that HARMALINE reduce SEIZURE THRESHOLD dose dependent significantly.

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APA: Copy

VAEZI, GH.H., TORABI, M., & SHIRAVI, A.. (2010). DETERMINATION OF SEIZURE THRESHOLD DUE TO INTRAPRITONEAL INJECTION OF HARMALINE IN NMRI MICE. JOURNAL OF ANIMAL BIOLOGY, 2(3), 43-50. SID. https://sid.ir/paper/176928/en

Vancouver: Copy

VAEZI GH.H., TORABI M., SHIRAVI A.. DETERMINATION OF SEIZURE THRESHOLD DUE TO INTRAPRITONEAL INJECTION OF HARMALINE IN NMRI MICE. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2010;2(3):43-50. Available from: https://sid.ir/paper/176928/en

IEEE: Copy

GH.H. VAEZI, M. TORABI, and A. SHIRAVI, “DETERMINATION OF SEIZURE THRESHOLD DUE TO INTRAPRITONEAL INJECTION OF HARMALINE IN NMRI MICE,” JOURNAL OF ANIMAL BIOLOGY, vol. 2, no. 3, pp. 43–50, 2010, [Online]. Available: https://sid.ir/paper/176928/en

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