EFFECT OF ATORVASTATIN ON PENTYLENETETRAZOL-INDUCED THRESHOLD SEIZURES IN GONADECTOMIZED MALE MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AZIZI SUMAYEH; HEYDARIEH NASRIN; JMALU FATEMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2016 | Volume:24 | Issue:7 Page(s): 0-0

Download Full-Text

Persian Verion

View:

835

Download:

Cites:

Information Journal Paper

Title

EFFECT OF ATORVASTATIN ON PENTYLENETETRAZOL-INDUCED THRESHOLD SEIZURES IN GONADECTOMIZED MALE MICE

Author(s)

AZIZI SUMAYEH | HEYDARIEH NASRIN | JMALU FATEMEH | Issue Writer Certificate

Keywords

ATORVASTATINQ2

EPILEPSYQ2

MALE MICEQ2

PENTYLENETETRAZOLQ2

SEIZURE THRESHOLDQ3

VASECTOMYQ2

Abstract

Introduction: EPILEPSY is a central nervous system disorder that appears as sudden convulsions, and transient, repetitive and unpredictable movement, with sensory- motor and autonomic sources. Statins are a group of blood cholesterol-lowering drugs. According to the results of the anti-inflammatory and vasoprotective effects of statins on cultured brain cells (astrocytes and microglia) and endothelial cells, the purpose of this study was investigating the effect of ATORVASTATIN on pentilentetrazole- induced seizures in gonadectomized MALE MICE.Methods: 36 male NMRI mice, weighting 30-35 g were used in the study. The mice were divided into two groups (Each group consisted of 18 mice: healthy and gonadectomized groups. The surgical removal of the testicles was gonadectomy and injections were given intraperitoneally. In gonadectomized group, an operation to remove the testicles was done. The DMSO group (0/3 cc) and treatment group were received ATORVASTATIN (10 mg/kg) intraperitoneally and then 30 minutes after that they received PTZ (80 mg/kg) injection. All injections were administered intraperitoneally. After injection of PTZ- duration of seizure onset (threshold) was recorded. The data were analyzed by one way variance analysis and Tukey’s test using SPSS (p<0. 05).Results: In healthy group, receiving ATORVASTATIN significantly increased the time of seizure onset (threshold) compared to solvent DMSO group and on the other hand gonadectomized mice had a significant reduction in the duration of seizures than normal mice (p<0. 001).Conclusion: The results indicated that the ATORVASTATIN had anticonvulsant effects and gonadectomy increases seizures.

Cites

No record.

References

No record.

Cite

APA: Copy

AZIZI, SUMAYEH, HEYDARIEH, NASRIN, & JMALU, FATEMEH. (2016). EFFECT OF ATORVASTATIN ON PENTYLENETETRAZOL-INDUCED THRESHOLD SEIZURES IN GONADECTOMIZED MALE MICE. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(7), 0-0. SID. https://sid.ir/paper/356935/en

Vancouver: Copy

AZIZI SUMAYEH, HEYDARIEH NASRIN, JMALU FATEMEH. EFFECT OF ATORVASTATIN ON PENTYLENETETRAZOL-INDUCED THRESHOLD SEIZURES IN GONADECTOMIZED MALE MICE. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(7):0-0. Available from: https://sid.ir/paper/356935/en

IEEE: Copy

SUMAYEH AZIZI, NASRIN HEYDARIEH, and FATEMEH JMALU, “EFFECT OF ATORVASTATIN ON PENTYLENETETRAZOL-INDUCED THRESHOLD SEIZURES IN GONADECTOMIZED MALE MICE,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 7, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/356935/en

Related Journal Papers