CENTRAL ADMINISTRATION OF PEGANUM HARMALA SEEDS METHANOLIC EXTRACT INCREASES FEAR BEHAVIOR IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAEZI GH.H.; FEREYDOUNI MASOUD; ETEMADI L.; SABZALI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2008 | Volume:11 | Issue:4 Page(s): 300-305

Download Full-Text

Persian Verion

View:

1,139

Download:

Cites:

Information Journal Paper

Title

CENTRAL ADMINISTRATION OF PEGANUM HARMALA SEEDS METHANOLIC EXTRACT INCREASES FEAR BEHAVIOR IN RATS

Author(s)

VAEZI GH.H. | FEREYDOUNI MASOUD | ETEMADI L. | SABZALI M. | Issue Writer Certificate

Keywords

PEGANUM HARMALAQ3

I.C.VQ3

PLUS-MAZEQ2

METHANOLIC EXTRACTQ3

RATQ3

Abstract

Introduction: Traditionally, PEGANUM HARMALA seeds (P.h) have been extensively used in the Asia region. We have previously reported the increase of fear behavior by systemic administration of P.h extract. Here, we evaluated the effect of central administration of the extract on the fear behavior.Method: METHANOLIC EXTRACT of the plant's seeds (37% humidity) was prepared for the investigation. Elevated plusmaze apparatus was used for evaluating the fear behavior. Adult male RATs were categorized in 7 main groups (n=6). 1) Sham control (saline 1 ul/rat, I.C.V) 2) Harmaline treated group (50 ug/rat, I.C.V). 3) Extract treated groups (10, 20, 25, 50, 100 ug/rat I.C.V respectively).Results: All the doses of the P.h METHANOLIC EXTRACT as like as harmaline caused fear behavior (p<0.05). There was no significant difference between the effects of harmaline and the doses of the plant extract.Discussion: Overall, it is possible that the main alkaloid of the P.h (harmaline) is responsible for the increasing of fear behavior. The effect seems to be done trough the central nervous system neurochemical mechanisms.

Cites

DETERMINATION OF SEIZURE THRESHOLD DUE TO INTRAPRITONEAL INJECTION OF HARMALINE IN NMRI MICE

References

No record.

Cite

APA: Copy

VAEZI, GH.H., FEREYDOUNI, MASOUD, ETEMADI, L., & SABZALI, M.. (2008). CENTRAL ADMINISTRATION OF PEGANUM HARMALA SEEDS METHANOLIC EXTRACT INCREASES FEAR BEHAVIOR IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(4), 300-305. SID. https://sid.ir/paper/75150/en

Vancouver: Copy

VAEZI GH.H., FEREYDOUNI MASOUD, ETEMADI L., SABZALI M.. CENTRAL ADMINISTRATION OF PEGANUM HARMALA SEEDS METHANOLIC EXTRACT INCREASES FEAR BEHAVIOR IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;11(4):300-305. Available from: https://sid.ir/paper/75150/en

IEEE: Copy

GH.H. VAEZI, MASOUD FEREYDOUNI, L. ETEMADI, and M. SABZALI, “CENTRAL ADMINISTRATION OF PEGANUM HARMALA SEEDS METHANOLIC EXTRACT INCREASES FEAR BEHAVIOR IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 4, pp. 300–305, 2008, [Online]. Available: https://sid.ir/paper/75150/en

Related Journal Papers