THE EFFECT OF L-NAME IN THE VENTRAL TEGMENTAL AREA IN THE IMPROVING EFFECT OF NICOTINE ON AMNESIA INDUCED BY MORPHINE ON ADULT MALE RATS

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PIRI M.; SHAHIN M.; MALEKI M.; ZARRINDAST M.

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2010 | Volume:3 | Issue:1 Page(s): 11-20

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Title

THE EFFECT OF L-NAME IN THE VENTRAL TEGMENTAL AREA IN THE IMPROVING EFFECT OF NICOTINE ON AMNESIA INDUCED BY MORPHINE ON ADULT MALE RATS

Author(s)

PIRI M. | SHAHIN M. | MALEKI M. | ZARRINDAST M. | Issue Writer Certificate

Keywords

VENTRAL TEGMENTAL AREAQ3

L-NAMEQ2

NICOTINEQ3

RATQ2

Abstract

Nitric oxide synthase has been detected in VENTRAL TEGMENTAL AREA, which is a key brain region that seems mediate behavioral effect of morphine and NICOTINE. In the present study, the possible involvement of L-NAME, a nitric oxide synthase inhibitor, in the VENTRAL TEGMENTAL AREA in NICOTINE’s effect on morphine state-dependent learning was investigated. This experimental study was performed on 300 Adult male Wistar RATs. RATs were anesthetized with ketamine hydrochloride, plus xylazine and then placed in a stereotaxic apparatus. Two stainless-steel cannuale were placed in the VENTRAL TEGMENTAL AREA. The animals trained in a step-through type inhibitory avoidance task, and tested 24h after training to measure step-through latency for the assessment of memory in male Wistar RATs. Post-training or pre-test injection of morphine (5 and 7.5 mg/kg) caused amnesia. The amnesia induced by post-training administration of morphine restored by pretest injection of morphine (5 and 7.5 mg/kg) or NICOTINE (0.5 and 1 mg/kg). Interestingly, pre-test co-administration of ineffective doses of NICOTINE (0.05 and 0.1 mg/kg) plus ineffective dose of morphine (2.5 mg/kg) reversed the amnesia induced by morphine. Pre-test injection of L-NAME (1 and 2 mg/rat, intra-VTA) by itself impairs memory and prevents the NICOTINE reversal of morphine effect on memory. The ensemble of these observations suggests that morphine-induced state-dependent learning can be modulated through the nicotinic and nitric oxide systems.

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APA: Copy

PIRI, M., SHAHIN, M., MALEKI, M., & ZARRINDAST, M.. (2010). THE EFFECT OF L-NAME IN THE VENTRAL TEGMENTAL AREA IN THE IMPROVING EFFECT OF NICOTINE ON AMNESIA INDUCED BY MORPHINE ON ADULT MALE RATS. JOURNAL OF ANIMAL BIOLOGY, 3(1), 11-20. SID. https://sid.ir/paper/176960/en

Vancouver: Copy

PIRI M., SHAHIN M., MALEKI M., ZARRINDAST M.. THE EFFECT OF L-NAME IN THE VENTRAL TEGMENTAL AREA IN THE IMPROVING EFFECT OF NICOTINE ON AMNESIA INDUCED BY MORPHINE ON ADULT MALE RATS. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2010;3(1):11-20. Available from: https://sid.ir/paper/176960/en

IEEE: Copy

M. PIRI, M. SHAHIN, M. MALEKI, and M. ZARRINDAST, “THE EFFECT OF L-NAME IN THE VENTRAL TEGMENTAL AREA IN THE IMPROVING EFFECT OF NICOTINE ON AMNESIA INDUCED BY MORPHINE ON ADULT MALE RATS,” JOURNAL OF ANIMAL BIOLOGY, vol. 3, no. 1, pp. 11–20, 2010, [Online]. Available: https://sid.ir/paper/176960/en

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