THE EFFECT OF L-ARGININE IN THE VENTRAL TEGMENTA AREA ON THE IMPROVING EFFECT OF NICOTINE ON MEMORY

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SHAHIN M.S.; PIRI M.; ZARRINDAST M.R.

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Journal: Qom University of Medical Sciences Journal Year:2012 | Volume:6 | Issue:3 (23) Page(s): 14-21

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Title

THE EFFECT OF L-ARGININE IN THE VENTRAL TEGMENTA AREA ON THE IMPROVING EFFECT OF NICOTINE ON MEMORY

Author(s)

SHAHIN M.S. | PIRI M. | ZARRINDAST M.R. | Issue Writer Certificate

Keywords

VENTRAL TEGMENTAL AREAQ2

MORPHINEQ2

NICOTINEQ2

NITRIC OXIDEQ2

Abstract

Background and Objectives: NITRIC OXIDE synthesis has been detected in VENTRAL TEGMENTAL AREA, which is a key brain region that seems to mediate behavioral effect of MORPHINE and NICOTINE. In the present study, the effects of L-arginine, a NITRIC OXIDE precursor, in the VENTRAL TEGMENTAL AREA in NICOTINE’s effect on MORPHINE-induced amnesia has been investigated.Methods: This study was done experimentally on 250 male rats. Rats were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine and then placed in a stereotaxic apparatus. Two stainless-steel cannuale were placed in the VENTRAL TEGMENTAL AREA. The behavioral testing was started in inhibitory avoidance task, and the step-through latency for entering into the dark compartment was measured for the assessment of memory retention. One-side analysis of variance (ANOVA) and Tukey test were used to evaluate the statistical significance between experimental groups. A difference of p<0.05 was considered statistically significant.Results: Post-training injection of MORPHINE (5 and 7.5 mg/kg) decreased the memory retrieval. Injection of NICOTINE or L-arginine before test by itself has no effect on memory retrieval. On the other hand, pre-test administration of MORPHINE (7.5 mg/kg), NICOTINE (0.5 and 1 mg/kg), L-arginine or ineffective doses of L-arginine plus non-effective dose of NICOTINE restored memory impairment induced by post-training injection of MORPHINE.Conclusion: The finding of the study indicate that NITRIC OXIDE system of the VENTRAL TEGMENTAL AREA may play an important role in the improving effect of NICOTINE on the MORPHINE-induced amnesia.

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APA: Copy

SHAHIN, M.S., PIRI, M., & ZARRINDAST, M.R.. (2012). THE EFFECT OF L-ARGININE IN THE VENTRAL TEGMENTA AREA ON THE IMPROVING EFFECT OF NICOTINE ON MEMORY. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 6(3 (23)), 14-21. SID. https://sid.ir/paper/132203/en

Vancouver: Copy

SHAHIN M.S., PIRI M., ZARRINDAST M.R.. THE EFFECT OF L-ARGININE IN THE VENTRAL TEGMENTA AREA ON THE IMPROVING EFFECT OF NICOTINE ON MEMORY. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2012;6(3 (23)):14-21. Available from: https://sid.ir/paper/132203/en

IEEE: Copy

M.S. SHAHIN, M. PIRI, and M.R. ZARRINDAST, “THE EFFECT OF L-ARGININE IN THE VENTRAL TEGMENTA AREA ON THE IMPROVING EFFECT OF NICOTINE ON MEMORY,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 6, no. 3 (23), pp. 14–21, 2012, [Online]. Available: https://sid.ir/paper/132203/en

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