The Effect of Intra-ventral Tegmental Area Injection of Ghrelin on Morphine-Induced Amnesia in Male Rats: An Experimental Study

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NAZARI SERENJEH F.; DARBANDI N.; YADEGARI A.; MOMENI H.R.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2019 | Volume:18 | Issue:2 Page(s): 147-160

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Title

The Effect of Intra-ventral Tegmental Area Injection of Ghrelin on Morphine-Induced Amnesia in Male Rats: An Experimental Study

Author(s)

NAZARI SERENJEH F. | DARBANDI N. | YADEGARI A. | MOMENI H.R. | Issue Writer Certificate

Keywords

GhrelinQ2

Inhibitory avoidance learningQ2

Male ratQ2

MorphineQ2

Ventral tegmentum areaQ2

Abstract

Background and Objectives: Extensive evidence shows that Morphine impairs cognitive functions. On the other hand, Ghrelin is a gastrointestinal hormone that affects learning and memory process. The purpose of the current study was to evaluate the effect of intra-ventral tegmental area (VTA) injection of Ghrelin on Morphineinduced amnesia in Male rats. Materials and Methods: In this experimental study, 104 male Wistar rats (220-250 g) were randomly divided into 13 groups (n=8 for all groups) including: saline, Morphine treated groups (0. 5-7. 5 mg/kg), Ghrelin treatd groups (0-3 nmol/μ l) plus Morphine (7. 5 mg/kg) or saline. Memory was measured in a step-through type inhibitory avoidance apparatus. All groups received intra-ventral tegmental area (intra-VTA) injection of saline or Ghrelin immediately after training. After 5 mins saline or Morphine was injected subcutaneously. Testing phase was done 24 hrs after training. Data were analyzed using one-way and two-way ANOVA analysis followed by Tukey’ s multiple comparison test. Results: The results showed that post-training administration of Morphine significantly reduced step-through latency compared with the saline group (p<0. 001). Intra-VTA injection of Ghrelin also reduced Morphineinduced amnesia (7. 5 mg/kg) (p< 0. 001). Ghrelin plus saline administration had no significant effect on memory retrieval (p>0. 05). Conclusion: The results indicate that intra-VTA injction of Ghrelin prevents the disrupting effects of Morphine on avoidance memory.

Cites

The Role of Middle Septal Ghrelin Receptors in the Effects of Morphine on Memory Consolidation in Passive Avoidance Learning

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APA: Copy

NAZARI SERENJEH, F., DARBANDI, N., YADEGARI, A., & MOMENI, H.R.. (2019). The Effect of Intra-ventral Tegmental Area Injection of Ghrelin on Morphine-Induced Amnesia in Male Rats: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 18(2 ), 147-160. SID. https://sid.ir/paper/71480/en

Vancouver: Copy

NAZARI SERENJEH F., DARBANDI N., YADEGARI A., MOMENI H.R.. The Effect of Intra-ventral Tegmental Area Injection of Ghrelin on Morphine-Induced Amnesia in Male Rats: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2019;18(2 ):147-160. Available from: https://sid.ir/paper/71480/en

IEEE: Copy

F. NAZARI SERENJEH, N. DARBANDI, A. YADEGARI, and H.R. MOMENI, “The Effect of Intra-ventral Tegmental Area Injection of Ghrelin on Morphine-Induced Amnesia in Male Rats: An Experimental Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 18, no. 2 , pp. 147–160, 2019, [Online]. Available: https://sid.ir/paper/71480/en

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