EFFECTS OF REVERSIBLE INACTIVATION OF THE VENTRAL TEGMENTAL AREA ON THE FIRING RATE OF NEURONS IN THE SHELL SUB-REGION OF THE NUCLEUS ACCUMBENS AND ON MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN THE RAT

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HAGHPARAST ABBAS; MOADDAB MAHSA; EBRAHIMZADEH SARVESTANI MOHAMMAD; KERMANI MOJTABA

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Journal: Koomesh Year:2012 | Volume:13 | Issue:2 (42) Page(s): 189-200

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Title

EFFECTS OF REVERSIBLE INACTIVATION OF THE VENTRAL TEGMENTAL AREA ON THE FIRING RATE OF NEURONS IN THE SHELL SUB-REGION OF THE NUCLEUS ACCUMBENS AND ON MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN THE RAT

Author(s)

HAGHPARAST ABBAS | MOADDAB MAHSA | EBRAHIMZADEH SARVESTANI MOHAMMAD | KERMANI MOJTABA | Issue Writer Certificate

Keywords

VENTRAL TEGMENTAL AREAQ2

NUCLEUS ACCUMBENSQ3

REVERSIBLE INACTIVATIONQ3

FIRING RATEQ2

CONDITIONED PLACE PREFERENCEQ2

MORPHINEQ2

RATQ2

Abstract

Introduction: The mesolimbic dopaminergic system that projects from the VENTRAL TEGMENTAL AREA (VTA) to the NUCLEUS ACCUMBENS (NAc) is critical for initiation of opioid reinforcement and reward-related effects of drugs of abuse. In the present study, the effects of REVERSIBLE INACTIVATION of VTA on RATE/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> FIRING RATE of NUCLEUS ACCUMBENS neurons and on acquisition and expression of MORPHINE-induced CONDITIONED PLACE PREFERENCE (CPP) were investigated in RATs.Materials and Methods: Adult male Wistar RATs were used in these experiments. In behavioral study, the REVERSIBLE INACTIVATION of VTA was done through bilateral intra-VTA microinjection of 2% lidocaine during the acquisition and expression of MORPHINE (5 mg/kg; s.c.)-induced CPP and in electrophysiology section, it was done through unilateral intra-VTA microinjection of 2% lidocaine during single unit recording from the NAc neurons. Conditioning score and locomotor activity were recorded by Ethovision software. RATE/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> FIRING RATE of neurons was recorded by single unit recording technique.Result: The results showed that bilateral intra-VTA administration of lidocaine significantly decreases the acquisition (P<0.01) and expression (P<0.05) of MORPHINE-induced CPP compared to their respective saline-microinjected groups. Moreover, intra-VTA administration of lidocaine had no effect on locomotor activity in these experiments. Also, unilateral intra-VTA administration of lidocaine significantly increased the RATE/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> FIRING RATE of NUCLEUS ACCUMBENS neurons.Conclusion: Our results further support the idea that VTA may play an important role in the acquisition and expression of MORPHINE-induced CPP.

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APA: Copy

HAGHPARAST, ABBAS, MOADDAB, MAHSA, EBRAHIMZADEH SARVESTANI, MOHAMMAD, & KERMANI, MOJTABA. (2012). EFFECTS OF REVERSIBLE INACTIVATION OF THE VENTRAL TEGMENTAL AREA ON THE FIRING RATE OF NEURONS IN THE SHELL SUB-REGION OF THE NUCLEUS ACCUMBENS AND ON MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN THE RAT. KOOMESH, 13(2 (42)), 189-200. SID. https://sid.ir/paper/36932/en

Vancouver: Copy

HAGHPARAST ABBAS, MOADDAB MAHSA, EBRAHIMZADEH SARVESTANI MOHAMMAD, KERMANI MOJTABA. EFFECTS OF REVERSIBLE INACTIVATION OF THE VENTRAL TEGMENTAL AREA ON THE FIRING RATE OF NEURONS IN THE SHELL SUB-REGION OF THE NUCLEUS ACCUMBENS AND ON MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN THE RAT. KOOMESH[Internet]. 2012;13(2 (42)):189-200. Available from: https://sid.ir/paper/36932/en

IEEE: Copy

ABBAS HAGHPARAST, MAHSA MOADDAB, MOHAMMAD EBRAHIMZADEH SARVESTANI, and MOJTABA KERMANI, “EFFECTS OF REVERSIBLE INACTIVATION OF THE VENTRAL TEGMENTAL AREA ON THE FIRING RATE OF NEURONS IN THE SHELL SUB-REGION OF THE NUCLEUS ACCUMBENS AND ON MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN THE RAT,” KOOMESH, vol. 13, no. 2 (42), pp. 189–200, 2012, [Online]. Available: https://sid.ir/paper/36932/en

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