OXIDATIVE DAMAGE TO DNA AND LIPIDS: CORRELATION WITH PROTEIN GLYCATION IN PATIENTS WITH TYPE 1 DIABETES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GOUDARZI M.T.; NAVIDI ABBAS POUR A.A.; REZAEI MOHSEN; BABA AHMADI REZAEI H.; ANSARI MOSTAFA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Clinical Medicine Year:2008 | Volume:14 | Issue:4 (SN 46) Page(s): 33-37

Download Full-Text

Persian Verion

View:

1,190

Download:

Cites:

Information Journal Paper

Title

OXIDATIVE DAMAGE TO DNA AND LIPIDS: CORRELATION WITH PROTEIN GLYCATION IN PATIENTS WITH TYPE 1 DIABETES

Author(s)

Keywords

DIABETES TYPE 1Q3

GLYCATED HEMOGLOBINQ3

OXIDATIVE DAMAGE TO DNAQ3

8-HYDROXYDEOXYGUANOSINEQ3

Abstract

Background & Objective: Diabetic hyperglycemia is associated with increased production of Reactive Oxygen Species (ROS). ROS reacts with DNA results in products such as 8- hydroxydeoxyguanosine that excrete in urine due to DNA repair processes. This study aims to evaluate correlation between oxidative damage of DNA and protein glycation in patients with Type 1 diabetes. We measured urinary 8-0HdG level in diabetic and control group and evaluated its correlation to GLYCATED HEMOGLOBIN (HbA1c) and glycated serum protein (GSP) levels. Furthermore plasma malondialdehyde (MDA) level was measured as an important indicator of lipid peroxidation in diabetes.Materials & Methods: We studied 32 patients with diabetes mellitus Type 1 and compared them with 48 sex and age-matched non-diabetic controls. GSP and MDA measurement were made by colorimetric assay. Hemoglobin Ale measured by ion-exchange chromatography method and urinary 8-0HdG measurement was made by competitive in vitro enzyme-linked immunosorbent assay (ELISA). Results: In the present study urinary 8-0HdG, blood HbA1c, plasma MDA and GSP levels were significantly higher in diabetics comparing to the control subjects (P<0.05). Furthermore, we found significant correlation between urinary 8-OHdG and HbA1c (P<0.05) in diabetic group. In addition, fasting blood sugar showed significant correlation with GSP and MDA (P<0.05). However the correlation of MDA with HbA1c was not significant in diabetic patients.Conclusion: This case-control study in young diabetic patients showed that increased blood glucose and related metabolic disorders result in oxidative stress and OXIDATIVE DAMAGE TO DNA and lipids. Furthermore OXIDATIVE DAMAGE TO DNA correlated to glycemic control, while there was no significant correlation between lipid peroxidation and the level of HbA1c.

Cites

No record.

References

اندازه گیری پروتئین های گلیکوزیله سرم به روش اصلاح شده تیوباربیتوریک اسید

Cite

APA: Copy

GOUDARZI, M.T., NAVIDI ABBAS POUR, A.A., REZAEI, MOHSEN, BABA AHMADI REZAEI, H., & ANSARI, MOSTAFA. (2008). OXIDATIVE DAMAGE TO DNA AND LIPIDS: CORRELATION WITH PROTEIN GLYCATION IN PATIENTS WITH TYPE 1 DIABETES. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 14(4 (SN 46)), 33-37. SID. https://sid.ir/paper/17799/en

Vancouver: Copy

GOUDARZI M.T., NAVIDI ABBAS POUR A.A., REZAEI MOHSEN, BABA AHMADI REZAEI H., ANSARI MOSTAFA. OXIDATIVE DAMAGE TO DNA AND LIPIDS: CORRELATION WITH PROTEIN GLYCATION IN PATIENTS WITH TYPE 1 DIABETES. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2008;14(4 (SN 46)):33-37. Available from: https://sid.ir/paper/17799/en

IEEE: Copy

M.T. GOUDARZI, A.A. NAVIDI ABBAS POUR, MOHSEN REZAEI, H. BABA AHMADI REZAEI, and MOSTAFA ANSARI, “OXIDATIVE DAMAGE TO DNA AND LIPIDS: CORRELATION WITH PROTEIN GLYCATION IN PATIENTS WITH TYPE 1 DIABETES,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 14, no. 4 (SN 46), pp. 33–37, 2008, [Online]. Available: https://sid.ir/paper/17799/en

Related Journal Papers