CANDIDATE GENE ANALYSIS IN T1DM: IFN-Y GENE

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TAVAKOLI BAZAZ J.; PRAVICA V.; BOULTON A.; HUTCHINSON I.V.

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Journal: Iranian Journal of Diabetes and Metabolism Year:2007 | Volume:6 | Issue:4 Page(s): 319-325

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Title

CANDIDATE GENE ANALYSIS IN T1DM: IFN-Y GENE

Author(s)

TAVAKOLI BAZAZ J. | PRAVICA V. | BOULTON A. | HUTCHINSON I.V. | Issue Writer Certificate

Keywords

GENETICQ3

POLYMORPHISMQ2

DIABETESQ2

IFN-YQ3

Abstract

Background: IFN-g is one of the most essential and fundamental player in initiation and development of T1DM. This mediator belongs to T Helper-1(Th1) class of cytokines and exerts stimulation and differentiation of naïve T cells towards Th1 cells and meanwhile inhibits differentiation and proliferation of Th2 cells. These effects are highly important in induction and progression of cell mediated immune responses that are aberrantly operative in development of T1DM. Due to such outstanding role, numerous studies including GENETIC manipulation have focused on the role of this pro-inflammatory cytokine in T1DM.Methods: In a GENETIC association study the influence of IFN-g gene variation in position +874*T/A on development of T1DM was analysed in 248 British Caucasian T1DM patients in comparison with 119 healthy matched controls. ARMS-PCR procedure was designed for detection of the variants at allele/genotype level.Results: No significant association between IFN-g gene POLYMORPHISM and T1DM was apparent (P³0.05). The distribution of these polymorphic variants was in Hardy-Weinberg equilibrium.Conclusion: While some studies have shown an association between the examined POLYMORPHISM of IFN-g and T1DM, our data do not support that. According to present study the selected polymorphic marker (+874*T/A) is not among the POLYMORPHISMs that governs in part GENETIC susceptibility to T1DM. That irreproducibility or controversial results is a common observation in GENETIC studies of complex traits such as T1DM, reflecting a fragile correlation between genotype and phenotype. This study also underlines the importance of replication of association studies to confirm the previous results/interpretations.

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APA: Copy

TAVAKOLI BAZAZ, J., PRAVICA, V., BOULTON, A., & HUTCHINSON, I.V.. (2007). CANDIDATE GENE ANALYSIS IN T1DM: IFN-Y GENE. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 6(4), 319-325. SID. https://sid.ir/paper/53886/en

Vancouver: Copy

TAVAKOLI BAZAZ J., PRAVICA V., BOULTON A., HUTCHINSON I.V.. CANDIDATE GENE ANALYSIS IN T1DM: IFN-Y GENE. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2007;6(4):319-325. Available from: https://sid.ir/paper/53886/en

IEEE: Copy

J. TAVAKOLI BAZAZ, V. PRAVICA, A. BOULTON, and I.V. HUTCHINSON, “CANDIDATE GENE ANALYSIS IN T1DM: IFN-Y GENE,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 6, no. 4, pp. 319–325, 2007, [Online]. Available: https://sid.ir/paper/53886/en

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