EFFECT OF SELEGILINE ON PITUITARY-GONAD AXIS AND SPERMATOGENESIS IN ADULT MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOKHTARI MOKHTAR; FESHARAKI MEHRAFARIN; MAKARIAN N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Clinical Medicine Year:2005 | Volume:12 | Issue:1 (SN 35) Page(s): 58-62

Download Full-Text

Persian Verion

View:

955

Download:

Cites:

Information Journal Paper

Title

EFFECT OF SELEGILINE ON PITUITARY-GONAD AXIS AND SPERMATOGENESIS IN ADULT MALE RATS

Author(s)

MOKHTARI MOKHTAR | FESHARAKI MEHRAFARIN | MAKARIAN N. | Issue Writer Certificate

Keywords

SELEGILINEQ3

SPERMATOGENESISQ3

PITUITARY-GONAD AXISQ3

RATSQ3

Abstract

SELEGILINE is an inhibitor of B-Mono amino oxidase (MAO-B). In view of its usages in treatment of nervous illnesses such as Parkinson's, Alzheimer's and depression the side effects of SELEGILINE on the endocrine axises are very important. In this research the effect of SELEGILINE on pituitary- gonad axis and SPERMATOGENESIS in adult male RATS were studied.For experimental and control groups 32 adult male RATS from wistar race were divided into 4 groups of 8. The experimental groups (B,C,D) were given oral doses of 5,10,15 (mg/kg.B.W) SELEGILINE for the period of 30 days and the control group (A) received saline. The blood samples were taken 8 hour after receiving last dose at 30th day and the concentration of LH, FSH and testosterone was measured by RIA. In adition at the 30th day the testes were separated and histological changes was studied among experimental and control groups. The results were evaluated by using ANOVA and Duncan test.The statistical analysis of the results indicated that receiving different dosages of SELEGILINE showed a significant increase in concentration of LH hormone in comparison with control group, but concentration of FSH did not show significant difference compared to the control group. In addition concentration of testosterone in response to different dosages in relative to the control group showed a significant decrease.According to the results we suggest that through LHincrease, SELEGILINE causes a decrease in concentration of testosterone via down-regulation receptors on leydig cells. Furthermore SELEGILINE causes increase in dopamine concentration in striatum area as an inhibitor of MAO-B and intern causes decrease in concentration of prolactin. The decrease in prolactin secretion reduces the effect of LH hormone on leydig cell. In addition histological studies showed significant effects caused by SELEGILINE such as decreased number of spermatozoa in somniferous tubules, leydig cells and reduced SPERMATOGENESIS, and these effects were dose dependent.

Cites

EFFECTS OF ORAL ADMINISTRATION OF RED PEPPER (CAPSICUM ANNUUM) AND BLACK PEPPER (PIPER NIGRUM) POWDERS ON PLASMA LEVELS OF PITUITARY-GONADS AXIS HORMONES IN MALE MICE

References

No record.

Cite

APA: Copy

MOKHTARI, MOKHTAR, FESHARAKI, MEHRAFARIN, & MAKARIAN, N.. (2005). EFFECT OF SELEGILINE ON PITUITARY-GONAD AXIS AND SPERMATOGENESIS IN ADULT MALE RATS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 12(1 (SN 35)), 58-62. SID. https://sid.ir/paper/17832/en

Vancouver: Copy

MOKHTARI MOKHTAR, FESHARAKI MEHRAFARIN, MAKARIAN N.. EFFECT OF SELEGILINE ON PITUITARY-GONAD AXIS AND SPERMATOGENESIS IN ADULT MALE RATS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2005;12(1 (SN 35)):58-62. Available from: https://sid.ir/paper/17832/en

IEEE: Copy

MOKHTAR MOKHTARI, MEHRAFARIN FESHARAKI, and N. MAKARIAN, “EFFECT OF SELEGILINE ON PITUITARY-GONAD AXIS AND SPERMATOGENESIS IN ADULT MALE RATS,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 12, no. 1 (SN 35), pp. 58–62, 2005, [Online]. Available: https://sid.ir/paper/17832/en

Related Journal Papers