GRANISETRON EFFECTS ON ECG IN CANCER PATIENTS RECEIVING CHEMOTHERAPY

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AZADEH P.; ALIDOUSTI A.; TASLIMI F.; VALAEI NASER

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Journal: Researcher Bulletin of Medical Sciences Year:2006 | Volume:11 | Issue:4 (52) Page(s): 241-244

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Title

GRANISETRON EFFECTS ON ECG IN CANCER PATIENTS RECEIVING CHEMOTHERAPY

Author(s)

AZADEH P. | ALIDOUSTI A. | TASLIMI F. | VALAEI NASER | Issue Writer Certificate

Keywords

GRANISETRONQ3

ELECTROCARDIOGRAMQ3

CANCERQ2

Abstract

Background: Considering the occurance of nausea and vomiting following chemotherapy in CANCER patient and 5HT3 receptor antagonist such as GRANISETRON usage for prophylaxis of this complication and some reports of ECG changes in these patients and deficiencies of previous studies, we conducted this study in patients referred to Imam Hosein hospital dunring 2005-6, to determine the GRANISETRON effects on ECG in CANCER patient receiving chemotherapy.Materials and Methods: This clinical trial was conducted on 54 patients. Confounding factors were excluded. ECG parameters including PR, QRS, QTc Intervals and heart rate of before and 90 minutes after GRANISETRON administration were determined and statistically assessed with paired-t-test and mann-u-whitney test.Results: After GRANISETRON administration in CANCER patient receiving chemotherapy PR and QTc intervals prolonged and heart rate decreased (p<0.0001), but there was no statistically meaningful difference between these ECG change based on type of chemotherapy regimen (with or without antryclines), type of CANCER (breast CANCER or other CANCERs) and age group (younger or older than 50 years). Therefore, QRS interval did not change statistically in this study.Conclusions: GRANISETRON caused PR and QTc prolongation and decrease of heart rate. Thus medical care of CANCER patients especially regarding their cardiac condition and drug usage appears reasonable and essencial.

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APA: Copy

AZADEH, P., ALIDOUSTI, A., TASLIMI, F., & VALAEI, NASER. (2006). GRANISETRON EFFECTS ON ECG IN CANCER PATIENTS RECEIVING CHEMOTHERAPY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 11(4 (52)), 241-244. SID. https://sid.ir/paper/18186/en

Vancouver: Copy

AZADEH P., ALIDOUSTI A., TASLIMI F., VALAEI NASER. GRANISETRON EFFECTS ON ECG IN CANCER PATIENTS RECEIVING CHEMOTHERAPY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2006;11(4 (52)):241-244. Available from: https://sid.ir/paper/18186/en

IEEE: Copy

P. AZADEH, A. ALIDOUSTI, F. TASLIMI, and NASER VALAEI, “GRANISETRON EFFECTS ON ECG IN CANCER PATIENTS RECEIVING CHEMOTHERAPY,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 11, no. 4 (52), pp. 241–244, 2006, [Online]. Available: https://sid.ir/paper/18186/en

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