CABERGOLIN VS BROMOCRIPTINE IN THE TREATMENT OF IDIOPATHIC GALACTORRHEA

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BAROUTI E.; BALASH F.; MAHMOUDI MOHAMMAD REZA; VALAEI NASER

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Journal: Researcher Bulletin of Medical Sciences Year:2006 | Volume:11 | Issue:4 (52) Page(s): 245-251

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Title

CABERGOLIN VS BROMOCRIPTINE IN THE TREATMENT OF IDIOPATHIC GALACTORRHEA

Author(s)

BAROUTI E. | BALASH F. | MAHMOUDI MOHAMMAD REZA | VALAEI NASER | Issue Writer Certificate

Keywords

IDIOPATHIC GALACTORRHEAQ3

HYPERPROLACTINEMIAQ3

DOPAMIN AGONISTQ3

Abstract

Background: Cabergolin is a new long acting dopamine-agonist drug with a low rate of side effects and well tolerated by patients and used in the treatment of HYPERPROLACTINEMIA. We conducted a research to compare the safety, efficacy, side effects and patient tolerance of cabergoline with those of bromocriptine which has been the standard therapy for IDIOPATHIC GALACTORRHEA.Materials and Methods: This open-labled study was done on 96 women diagnosed with IDIOPATHIC GALACTORRHEA randomly put in two groups of 48, one treated with cabergoline (0.25 mg-0.5 mg twice a week) another with bromocriptine (1.25mg-2.5 mg twice a day) for 12 weeks. Clinical status, symptoms, side effects and dosage assessment were examined in accordance with prolactine level every 2 weeks for one month and monthly thereafter.Results: Following results were achieved in two groups treated with bromocriptine and cabergoline respectively. Galactorrhea treatment (60.4% and 81%), normal level of prolactine (64.5% and 85.5%), menstrual disorder treated (37.5% and 61.5%).92 percent of patients were cured with bromocriptine and 100 percent with cabergoline. Side effects were recorded in 8504 percent of patients taken bromocriptine and 41.6 percent of those taken cabergoline. The side effects were similar in both groups and included gastrointestinal, neurological and cardiovascular symptoms. One patient discontinued taking cabergoline because of pregnancy and 4 patients coul not tolerated bromocriptine.Concussions: Both bromocriptine and cabergoline treated IDIOPATHIC GALACTORRHEA and normalized prolactine level but cabergoline is significantly more effective, better tolerated and has less side effects both in incidence and severity.

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APA: Copy

BAROUTI, E., BALASH, F., MAHMOUDI, MOHAMMAD REZA, & VALAEI, NASER. (2006). CABERGOLIN VS BROMOCRIPTINE IN THE TREATMENT OF IDIOPATHIC GALACTORRHEA. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 11(4 (52)), 245-251. SID. https://sid.ir/paper/18192/en

Vancouver: Copy

BAROUTI E., BALASH F., MAHMOUDI MOHAMMAD REZA, VALAEI NASER. CABERGOLIN VS BROMOCRIPTINE IN THE TREATMENT OF IDIOPATHIC GALACTORRHEA. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2006;11(4 (52)):245-251. Available from: https://sid.ir/paper/18192/en

IEEE: Copy

E. BAROUTI, F. BALASH, MOHAMMAD REZA MAHMOUDI, and NASER VALAEI, “CABERGOLIN VS BROMOCRIPTINE IN THE TREATMENT OF IDIOPATHIC GALACTORRHEA,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 11, no. 4 (52), pp. 245–251, 2006, [Online]. Available: https://sid.ir/paper/18192/en

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