EFFICACY OF NALTREXONE ON TREATMENT OF HYPERPROLACTINEMIA DUE TO USE OF TYPICAL ANTIPSYCHOTIC

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SHAMS J.; NOUROUZI A.R.; ARBABI MOHAMMAD; SAMIEI S.M.

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Journal: Researcher Bulletin of Medical Sciences Year:2006 | Volume:11 | Issue:4 (52) Page(s): 221-225

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Title

EFFICACY OF NALTREXONE ON TREATMENT OF HYPERPROLACTINEMIA DUE TO USE OF TYPICAL ANTIPSYCHOTIC

Author(s)

SHAMS J. | NOUROUZI A.R. | ARBABI MOHAMMAD | SAMIEI S.M. | Issue Writer Certificate

Keywords

HYPERPROLACTINEMIAQ3

NALTREXONEQ3

ANTIPSYCHOTIC DRUGSQ3

Abstract

Background: HYPERPROLACTINEMIAis a side effect of long-term administration of the ANTIPSYCHOTIC DRUGS. HYPERPROLACTINEMIAmay lead to osteoporosis, sexual dysfunction and behavioral problems such as anxiety, depression and aggression. Therefore, control of HYPERPROLACTINEMIA with a complementary agent is necessary. The present study was designed for evaluation of the effect of NALTREXONE on antipsychotic drug-induced HYPERPROLACTINEMIA in schizophrenic patients. Materials and Methods: 32 patients (8 males and 24 females) that received typical ANTIPSYCHOTIC DRUGS and had plasma prolactin levels over 20ng/ml, were studied according to a double-blind, randomized design. NALTREXONE was administrated twice daily for 6 weeks. Drug regimen of patients was stable during the period of study.Conclusions: Patients were divided randomly in two experimental groups (each group: 4 males and 12 females). Groups were match for age, sex, drug dosage, amenorrhea and smoking. Our data show that NALTREXONE failed to normalize the HYPERPROLACTINEMIA secondary to use of typical ANTIPSYCHOTIC DRUGS after 6 weeks (P=0.22). However, NALTREXONE may prevent the increment of serum prolactin level.Results: Prescription of NALTREXONE as an opioid antagonist had no effect on typical ANTIPSYCHOTIC DRUGS-induced HYPERPROLACTINEMIA.

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APA: Copy

SHAMS, J., NOUROUZI, A.R., ARBABI, MOHAMMAD, & SAMIEI, S.M.. (2006). EFFICACY OF NALTREXONE ON TREATMENT OF HYPERPROLACTINEMIA DUE TO USE OF TYPICAL ANTIPSYCHOTIC. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 11(4 (52)), 221-225. SID. https://sid.ir/paper/18194/en

Vancouver: Copy

SHAMS J., NOUROUZI A.R., ARBABI MOHAMMAD, SAMIEI S.M.. EFFICACY OF NALTREXONE ON TREATMENT OF HYPERPROLACTINEMIA DUE TO USE OF TYPICAL ANTIPSYCHOTIC. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2006;11(4 (52)):221-225. Available from: https://sid.ir/paper/18194/en

IEEE: Copy

J. SHAMS, A.R. NOUROUZI, MOHAMMAD ARBABI, and S.M. SAMIEI, “EFFICACY OF NALTREXONE ON TREATMENT OF HYPERPROLACTINEMIA DUE TO USE OF TYPICAL ANTIPSYCHOTIC,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 11, no. 4 (52), pp. 221–225, 2006, [Online]. Available: https://sid.ir/paper/18194/en

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