THE RELATIONSHIP OF BEING MAJOR AND MINOR THALASSAEMIAS WITH SERUM AND RBC FOLATE DEFICIENCY

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MOJTAHED ZADEH FEREYDOUN; KOUSARIAN M.; MAHDAVI M.R.; SHAH MORADI M.

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Journal: Researcher Bulletin of Medical Sciences Year:2007 | Volume:11 | Issue:6 (54) Page(s): 367-370

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Information Journal Paper

Title

THE RELATIONSHIP OF BEING MAJOR AND MINOR THALASSAEMIAS WITH SERUM AND RBC FOLATE DEFICIENCY

Author(s)

MOJTAHED ZADEH FEREYDOUN | KOUSARIAN M. | MAHDAVI M.R. | SHAH MORADI M. | Issue Writer Certificate

Keywords

THALASSAEMIAS MAJORQ3

FOLATE DEFICIENCYQ3

SUPPLEMENTATIONQ3

SERUM FOLATEQ3

THALASSAEMIAS MINORQ3

Abstract

Background: The development of extensive erythropoiesis has been recognized as the feature of major B thalassamia and to some extent minor thalassaemia. The aim of study was to investigate whether the patients with thalassemias need to receive folate supplements.Materials and Methods: This was a historical cohort study. Folatelevel in the serum and red blood cell samples measured using RIA method with Delshid Gamma counter. The normal level of the kit for folate was 3-16 ng/dl and 150-450 ng/dl in the serum and red blood cells respectively.Results: 18 families enrolled in this study. From each family three have been selected, two were thalassemics major and minor matched by age and another was a normal subject. The folate level in the serum was 0.98±1.15 and 7.1±3ng/dl in the B thalassemias major and minor groups respectively. IT was 6/5 1/4 in the normal subjects (p<0/0001). The level of folic acid in the red blood cells in the heterozygote thalassaemias and the normal group was 316±117and 227±120ng/dl, respectively (p<0/06).Conclusions: The study showed that folate SUPPLEMENTATION is necessary in the Thalassaemia major cases to prevent the folated deficiency but it is not necessary for B heterozygote thalassaemias.

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APA: Copy

MOJTAHED ZADEH, FEREYDOUN, KOUSARIAN, M., MAHDAVI, M.R., & SHAH MORADI, M.. (2007). THE RELATIONSHIP OF BEING MAJOR AND MINOR THALASSAEMIAS WITH SERUM AND RBC FOLATE DEFICIENCY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 11(6 (54)), 367-370. SID. https://sid.ir/paper/18202/en

Vancouver: Copy

MOJTAHED ZADEH FEREYDOUN, KOUSARIAN M., MAHDAVI M.R., SHAH MORADI M.. THE RELATIONSHIP OF BEING MAJOR AND MINOR THALASSAEMIAS WITH SERUM AND RBC FOLATE DEFICIENCY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2007;11(6 (54)):367-370. Available from: https://sid.ir/paper/18202/en

IEEE: Copy

FEREYDOUN MOJTAHED ZADEH, M. KOUSARIAN, M.R. MAHDAVI, and M. SHAH MORADI, “THE RELATIONSHIP OF BEING MAJOR AND MINOR THALASSAEMIAS WITH SERUM AND RBC FOLATE DEFICIENCY,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 11, no. 6 (54), pp. 367–370, 2007, [Online]. Available: https://sid.ir/paper/18202/en

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