SURVEYING THE EFFECT OF CEFTIZOXIM IN PREVENTION OF MENINGITIS IN PATIENTS WITH SKULL BASE FRACTURES

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MOHSENI M.; DOLATI P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:5 | Issue:4 (20) Page(s): 379-384

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Title

SURVEYING THE EFFECT OF CEFTIZOXIM IN PREVENTION OF MENINGITIS IN PATIENTS WITH SKULL BASE FRACTURES

Author(s)

MOHSENI M. | DOLATI P. | Issue Writer Certificate

Keywords

SKULL BASE FRACTUREQ4

MENINGITISQ3

PROPHYLAXISQ3

CEFTIZOXIMQ4

Abstract

Regarding the prevalence of SKULL BASE FRACTUREs and paradoxical approaches for administering or not administering antibiotics as PROPHYLAXIS, and also with respect to lack of experimental reports in this field, this study has been conducted over the traumatic patients referring to Shohada-e-Tajrish Hospital, 1999-2000, to determine the effects of CEFTIZOXIM as prophylactic agents on MENINGITIS. This sequential clinical trial performed on all head trauma patients with SKULL BASE FRACTUREs referring to Shohada-e- Tajrish Hospital. Patients were distributed in 2 groups of case (A) and control (B), randomly. In the case group, CEFTIZOXIM Amp, was administered by dose of 150 mg/kg/day either for three days or up to the cessation of rhinorrhea or otorrhea, but the control group received no antibiotic. Among 65 patients with SKULL BASE FRACTURE, 11 who had not met our criteria were eliminated. The remaining 54 patients were distributed as follow: 26 in the case group (receiving antibiotic) and 28 in the control group (not receiving antibiotic). Patients in both groups were matched according to the sex, age, site of fracture and the" incidence of CSF fistula. 4 patients (14.3%) in the case group and 3(11.5%) in the control group have been diagnosed with MENINGITIS, but no significant statistically difference has been noted. The presence of fistula was accompanied by higher rate of MENINGITIS incidence, where the difference was not significant. Culture was shown to be positive in 3 patients of 4 in the control group, whereas in the case group all of the patients have been proved to have negative culture. The study revealed that administering the antibiotic has no effect on MENINGITIS prevention. In the meantime, as none of our neurosurgical departments are faced with high numbers of patients with SKULL BASE FRACTURE multicentric research to survey the effects of prophylactic antibiotics, especially in case of CSF fistula, is strongly recommended.

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APA: Copy

MOHSENI, M., & DOLATI, P.. (2001). SURVEYING THE EFFECT OF CEFTIZOXIM IN PREVENTION OF MENINGITIS IN PATIENTS WITH SKULL BASE FRACTURES. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 5(4 (20)), 379-384. SID. https://sid.ir/paper/18373/en

Vancouver: Copy

MOHSENI M., DOLATI P.. SURVEYING THE EFFECT OF CEFTIZOXIM IN PREVENTION OF MENINGITIS IN PATIENTS WITH SKULL BASE FRACTURES. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;5(4 (20)):379-384. Available from: https://sid.ir/paper/18373/en

IEEE: Copy

M. MOHSENI, and P. DOLATI, “SURVEYING THE EFFECT OF CEFTIZOXIM IN PREVENTION OF MENINGITIS IN PATIENTS WITH SKULL BASE FRACTURES,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 5, no. 4 (20), pp. 379–384, 2001, [Online]. Available: https://sid.ir/paper/18373/en

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