EVALUATION OF THE EFFICACY OF CARBOMERIC POLYMERS AND SODIUM CARBOXY METHYL CELLULOSE IN THE PREPARATION OF SODIUM SALICYLATERELEASING MUCOADHESIVE BUCCAL PATCHES

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MORTAZAVI A.; ABOU FAZELI R.; SOLTANI M.

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Journal: Researcher Bulletin of Medical Sciences Year:2000 | Volume:5 | Issue:3 (19) Page(s): 277-288

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Title

EVALUATION OF THE EFFICACY OF CARBOMERIC POLYMERS AND SODIUM CARBOXY METHYL CELLULOSE IN THE PREPARATION OF SODIUM SALICYLATERELEASING MUCOADHESIVE BUCCAL PATCHES

Author(s)

MORTAZAVI A. | ABOU FAZELI R. | SOLTANI M. | Issue Writer Certificate

Keywords

BUCCAL PATCHQ4

P-934 CARBOMERQ4

SODIUM CARBOXY METHYL CELLULOSEQ4

MUCOADHESIVESQ4

MUCOADHESIVE STRENGTHQ4

DRUG RELEASEQ4

Abstract

One of the recent medicinal forms that is under research study is mucoadhesive BUCCAL PATCHes. These patches are thin and flexible and can adhere for a long time to the mucosal membrane and gradually and continuously release their chemicals. For this purpose, in this study the combination of carbomer polymers and SODIUM CARBOXY METHYL CELLULOSE (CMC) was investigated for release of sodium salicylate. For the preparation of patches, solvent moulding, polymer dissolution, adding of glycerin as a pliable substance for patch, addition of solution to mould and drying at a temperature of 37°C were applied. The results showed that carbomeric polymers can solely produce brittle patches, but their combination as CMC can produce appropriate patches. In this regard, patches containing carbomer P934 showed the highest adhesive strength and adhering time on intestinal mucosa of rat in phosphate buffer (pH=6.8). It was also determined that an appropriate patch should have a high adhesive power with a long life time for its adherence. Then the sodium salicylate was added to this formulation. These patches showed an appropriate appearance, strength (it is less than bodily patches), and a long life time for adherence. Evaluation of kinetics of sodium salicylate release from these patches showed 0°C kinetic pattern. It is concluded that this formulation is very appropriate for the preparation of MUCOADHESIVES.

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APA: Copy

MORTAZAVI, A., ABOU FAZELI, R., & SOLTANI, M.. (2000). EVALUATION OF THE EFFICACY OF CARBOMERIC POLYMERS AND SODIUM CARBOXY METHYL CELLULOSE IN THE PREPARATION OF SODIUM SALICYLATERELEASING MUCOADHESIVE BUCCAL PATCHES. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 5(3 (19)), 277-288. SID. https://sid.ir/paper/18389/en

Vancouver: Copy

MORTAZAVI A., ABOU FAZELI R., SOLTANI M.. EVALUATION OF THE EFFICACY OF CARBOMERIC POLYMERS AND SODIUM CARBOXY METHYL CELLULOSE IN THE PREPARATION OF SODIUM SALICYLATERELEASING MUCOADHESIVE BUCCAL PATCHES. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2000;5(3 (19)):277-288. Available from: https://sid.ir/paper/18389/en

IEEE: Copy

A. MORTAZAVI, R. ABOU FAZELI, and M. SOLTANI, “EVALUATION OF THE EFFICACY OF CARBOMERIC POLYMERS AND SODIUM CARBOXY METHYL CELLULOSE IN THE PREPARATION OF SODIUM SALICYLATERELEASING MUCOADHESIVE BUCCAL PATCHES,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 5, no. 3 (19), pp. 277–288, 2000, [Online]. Available: https://sid.ir/paper/18389/en

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