THE ROLE OF HELICOBACTER PYLORI INFECTION IN NON ULCER DYSPEPSIA AND THE EFFECTS OF THERAPY IN THIS GROUP

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ZOJAJI H.; MEHRABIAN A.A.; ANSARI F.; VALAEI NASER

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Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:6 | Issue:2 (22) Page(s): 167-171

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Title

THE ROLE OF HELICOBACTER PYLORI INFECTION IN NON ULCER DYSPEPSIA AND THE EFFECTS OF THERAPY IN THIS GROUP

Author(s)

ZOJAJI H. | MEHRABIAN A.A. | ANSARI F. | VALAEI NASER | Issue Writer Certificate

Keywords

HELICOBACTER PYLORI INFECTIONQ3

NUDQ4

Abstract

Background: Non Ulcer Dyspepsia (NUD) is among the most common causes of referring to gastroenterologists, which has unknown etiology. The role of HELICOBACTER PYLORI INFECTION in NUD and the effects of therapy are not obvious, and review of literature has shown deep controversies in this field. The present study has been conducted with the aim of determining the prevalence of HELICOBACTER PYLORI INFECTION and also the effects of therapy on symptoms removal in patients with NUD referring to Shohada-e – Tajrish hospital since 1996till 1998.Materials and methods: To determine the role of HELICOBACTER PYLORI INFECTION in NUD, a case-control study was conducted over 124 individuals (83 as the case and 41 as the control group), whereas, to survey the effects of therapy, an experimental study was performed over 36 individuals (18 as the case and 18 as the control group). The case group was received triple therapy of Bismuth sub citrate + Metronidazole + Amoxicillin, and the control was given Ranitidin + Antiacid. Then, the clinical features before and after the therapy was cOlllpared in both groups. The efficacy of therapy was assessed a month later with endoscopy and urease test.Results: The prevalence of HELICOBACTER PYLORI INFECTION was reported 43.3% and 19.5% in the case and control group, respectively. (p<0.01) HELICOBACTER PYLORI INFECTION has increased the risk of NUD incidence by 3.2. In the second phase, 36 patients with NUD were distributed in two groups of case (18) and control (18). They have been compared regarding the symptoms' severity after two and six weeks. At the end of the 2ndweek, nocturnal epigastria pain was the only symptom shown greater decrease in the case group (p<0.08), whereas, at the end of the 6thweek, both nocturnal and daily epigastric pain shown greater decrease in the case group. (p<0.05) Other symptoms have shown no significant difference between the two groups. Eradication of Helicobacter Pylori revealed to be successful in 66.6%.Conclusion: Patients with NUD are 3.2 times as likely as normal individuals to be infected with Helicobacter Pylori. Triple therapy seems to be effective in patients with NUD, especially for removal of nocturnal and daily epigastric pain.

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APA: Copy

ZOJAJI, H., MEHRABIAN, A.A., ANSARI, F., & VALAEI, NASER. (2001). THE ROLE OF HELICOBACTER PYLORI INFECTION IN NON ULCER DYSPEPSIA AND THE EFFECTS OF THERAPY IN THIS GROUP. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(2 (22)), 167-171. SID. https://sid.ir/paper/18416/en

Vancouver: Copy

ZOJAJI H., MEHRABIAN A.A., ANSARI F., VALAEI NASER. THE ROLE OF HELICOBACTER PYLORI INFECTION IN NON ULCER DYSPEPSIA AND THE EFFECTS OF THERAPY IN THIS GROUP. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;6(2 (22)):167-171. Available from: https://sid.ir/paper/18416/en

IEEE: Copy

H. ZOJAJI, A.A. MEHRABIAN, F. ANSARI, and NASER VALAEI, “THE ROLE OF HELICOBACTER PYLORI INFECTION IN NON ULCER DYSPEPSIA AND THE EFFECTS OF THERAPY IN THIS GROUP,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. 2 (22), pp. 167–171, 2001, [Online]. Available: https://sid.ir/paper/18416/en

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