Investigation of radioprotective effects of WR-1065 and acetylsalicylic acid by micronucleus assay

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Yalcin A.; Tabakcioglu K.; Caloglu V.Y.; Uzal C.; Omurlu I. K.

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Journal Paper

Paper Information

Journal: INTERNATIONAL JOURNAL OF RADIATION RESEARCH Year:2025 | Volume:23 | Issue:2 Page(s): 435-439

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Information Journal Paper

Title

Investigation of radioprotective effects of WR-1065 and acetylsalicylic acid by micronucleus assay

Author(s)

Keywords

Acetylsalicylic acid

WR-1065

micronucleus

radioprotection

ionizing radiation

Abstract

Background: The current study aimed to investigate the ability of acetylsalicylic acid (ASA) to prevent ionizing radiation-induced DNA damage in human lymphocytes via the micronucleus (MN) assay and compare it with the efficacy of the agent WR-1065 (2-[(3-Aminopropyl) amino] ethanethiol dihydrochloride), which exhibits radioprotective activity. Materials and Methods: Peripheral blood samples were obtained from four participants, and nine experimental groups were established. Blood samples were treated with 25 µg/mL ASA and 40 µg/mL WR-1065 for 30 min before irradiation. After treatment, the samples were irradiated with 6 MV X-rays in the linear accelerator (LINAC) unit at doses of 2 Gy and 4 Gy. All blood samples were then cultured for the micronucleus assay. Results: In vitro treatments with ASA and WR-1065 at the indicated doses did not result in statistically significant changes in MN frequencies (p˃0.05). Conclusion: Both drugs were did not exhibit radioprotective effects in the experimental model used.

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