Meta-analysis of c-Myc gene expression in prognosis of elderly patients with NSCLC underwent surgery and chemoradiotherapy

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Guo Z.L.

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Journal Paper

Paper Information

Journal: INTERNATIONAL JOURNAL OF RADIATION RESEARCH Year:2025 | Volume:23 | Issue:2 Page(s): 481-487

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Title

Meta-analysis of c-Myc gene expression in prognosis of elderly patients with NSCLC underwent surgery and chemoradiotherapy

Author(s)

Guo Z.L. | Issue Writer Certificate

Keywords

C-Myc gene expression

non-small cell lung cancer

chemoradiotherapy

meta-analysis.

Abstract

Background: This paper is conducted to analysis the effects of c-Myc gene expression on surgical intervention and outlook of elderly sufferers with Non-Small Cell Lung Cancer (NSCLC) through meta-analysis. Materials and Methods: Through searching the key words "small cell lung cancer, c-Myc" on China National Knowledge Internet (CNKI) and other platforms, the literature meeting the inclusion criteria was screened. Finally, a total of 14 relevant studies were included. Statistical methods were used to analyze the data, including calculation of standard deviation and 95% confidence interval, and for analysis, the fixed effects model was utilized. Results: Meta-analysis of untreated and healthy groups showed that serum c-Myc mRNA expression in untreated group is remarkably superior to healthy group (standard deviation -1.64, 95% confidence interval -1.85 to -1.45, P<0.001). In addition, serum c-Myc mRNA expression levels in elderly sufferers with NSCLC are remarkably superior to younger group (standard deviation 1.45, 95% confidence interval 1.15 to 1.74, P<0.001). In addition, serum c-Myc mRNA expression in the non-smoking group is remarkably superior to smoking group (OR=-1.78, 95% CI -1.95 to -1.60, P<0.001). Conclusions: Serum c-Myc mRNA expression levels in elderly NSCLC suffers are superior to healthy groups, which were related to age and smoking behavior. This finding is significant for the early screening, diagnosis and prognosis assessment of NSCLC, providing a basis for further research on the role of c-Myc gene in elderly NSCLC.

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