STUDY OF DETERMINATION OF MYOEPITHELIAL CELL MARKERS IN DIAGNOSIS OF PLEOMORPHIC ADENOMA AND MUCOEPIDERMOID CARCINOMA OF SALIVARY GLANDS

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DEYHIMI P.; MAHZOUNI P.; TORABINIA N.

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Journal: Researcher Bulletin of Medical Sciences Year:2005 | Volume:10 | Issue:3 (45) Page(s): 145-151

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Title

STUDY OF DETERMINATION OF MYOEPITHELIAL CELL MARKERS IN DIAGNOSIS OF PLEOMORPHIC ADENOMA AND MUCOEPIDERMOID CARCINOMA OF SALIVARY GLANDS

Author(s)

DEYHIMI P. | MAHZOUNI P. | TORABINIA N. | Issue Writer Certificate

Keywords

MUCOEPIDERMOID CARCINOMAQ4

PLEOMORPHIC ADENOMAQ3

GFAPQ4

MUSCLE SPECIFIC ACTINQ4

VIMENTINQ3

S100Q4

IMMUNOHISTOCHEMISTRYQ3

Abstract

Background: The application of IMMUNOHISTOCHEMISTRY methods has resulted in marked improvement of the microscopic diagnosis of neoplasms in combined with H&E staining. Although unique cellular antigen have not been found in salivary gland neoplasms, multiple less specific immuno markers have been used and may be helpful in elucidating the role of myoepithelial differentiation in those neoplasms. The aim of this study was to evaluate immunohistochemical myoepithelial markers (GFAP, actin, VIMENTIN and S100) in MUCOEPIDERMOID CARCINOMA and PLEOMORPHIC ADENOMA of salivary glands.Materials and methods: In a descriptive study, formalin-fixed and parafin embeded tissue sections of 25 PLEOMORPHIC ADENOMA and 25 MUCOEPIDERMOID CARCINOMA were immunohistochemically analyzed for the presence of actin, VIMENTIN, GFAP and S100 protein. A standard biotin-streptavidin procedure after antigen retrieval was used. Immunoreactivity of myoepithlial cells and chondromyxoid areas in PLEOMORPHIC ADENOMA and mucus cell, epidermoid cells and intermediate cells in MUCOEPIDERMOID CARCINOMA were evaluated and immunoreactivity was scored on a scale of 0 to +4 (Regezi method). Data were analyzed with chi-square test.Results: In 25 cases of PLEOMORPHIC ADENOMAs, all nonluminal cells and chondromyxoid areas were positive (+4) for GFAP and VIMENTIN and (O ® +3) for muscle-specific actin (12:0, 12:+1, 1:+3) and (+1®+4) for S100 protein (3:+1, 3:+2, 18:+3, 1:+4). But all MUCOEPIDERMOID CARCINOMAs regardless of their grade were negative for all mentioned markers (P<0.0001). There was no Immunohistochemical difference in major and minor salivary glands neoplasms.Conclusion: Expression of myoepithelial cell-associated markers in PLEOMORPHIC ADENOMA have confirmed role of myoepithelial cells in histogenesis of this tumor and lack or limited expression of these antigen in MUCOEPIDERMOID CARCINOMA, indicates the minimal myoepithelial differentiation in this tumor. Evaluation of myoepithelial cell markers can be helpful in differential diagnosis of salivary gland neoplasms with myoepithelial cell differentiation.

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APA: Copy

DEYHIMI, P., MAHZOUNI, P., & TORABINIA, N.. (2005). STUDY OF DETERMINATION OF MYOEPITHELIAL CELL MARKERS IN DIAGNOSIS OF PLEOMORPHIC ADENOMA AND MUCOEPIDERMOID CARCINOMA OF SALIVARY GLANDS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 10(3 (45)), 145-151. SID. https://sid.ir/paper/18433/en

Vancouver: Copy

DEYHIMI P., MAHZOUNI P., TORABINIA N.. STUDY OF DETERMINATION OF MYOEPITHELIAL CELL MARKERS IN DIAGNOSIS OF PLEOMORPHIC ADENOMA AND MUCOEPIDERMOID CARCINOMA OF SALIVARY GLANDS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2005;10(3 (45)):145-151. Available from: https://sid.ir/paper/18433/en

IEEE: Copy

P. DEYHIMI, P. MAHZOUNI, and N. TORABINIA, “STUDY OF DETERMINATION OF MYOEPITHELIAL CELL MARKERS IN DIAGNOSIS OF PLEOMORPHIC ADENOMA AND MUCOEPIDERMOID CARCINOMA OF SALIVARY GLANDS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 10, no. 3 (45), pp. 145–151, 2005, [Online]. Available: https://sid.ir/paper/18433/en

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