EVALUATION OF UNINARY N-ACETYL GLUCOSAMINIDASE AND ITS RELATED PRAMETERS IN PATIENTS WITH Β2-THALASSEMIA MAJOR, IN MOFID CHILDREN HOSPITAL, 1383

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MOHKAM M.; NARIMAN SH.; SHAMSIAN SH.; GACHKAR L.; ARZANIAN M.T.

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Journal: Researcher Bulletin of Medical Sciences Year:2005 | Volume:10 | Issue:3 (45) Page(s): 177-181

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Title

EVALUATION OF UNINARY N-ACETYL GLUCOSAMINIDASE AND ITS RELATED PRAMETERS IN PATIENTS WITH Β2-THALASSEMIA MAJOR, IN MOFID CHILDREN HOSPITAL, 1383

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Keywords

URINARY NAGQ4

TUBULOPATHYQ4

BETA THALASSEMIA MAJORQ3

Abstract

Background: There are few studies and variable data about renal dysfunction in thalassemic syndromes. Determination of URINARY NAG as the most important indicator for tubular involvement. can be considered. Due to lack of data in Iran, the aim of this study is detection of renal dysfunction and URINARY NAG concentration in major beta thalassemic patients.Materials and methods: This descriptive cross-sectional study conducted between Feb. 2004 Feb. 2005 on all beta thalassemic patients admited in out patient clinic of Mofid hospital for transfusion.Diagnosis was carried out by standard criteria. 103 beta-thalassemic patients with various disease severity were studied. The first fresh morning urine sample was collected and analyzed for sodium, potassium, calcium, creatinine, phosphate, uric acid, protein, NAG (N-acetyl-beta-D-glucosaminidase) and amino acids. A blood sample from each patient was collected for evaluation of complete blood count, fasting blood sugar and serum ferritin, sodium, potassium, creatinine, uric acid and amino acids. T-test, Chi2 and regression analysis (pearson correlation) were used for statistical analysis. Results: Mean age of patients was 12.5±5.53 year. 53.4% were female and remaining were male. The patients had significantly high levels of urine NAG (13.5±13 U/gr) in 35.3% (Cl: 26-45%) and abnormal FE-Na in 29.4%, abnormal FE-K in7.8% and abnormal U Ca/Cr in 22.5%. Mean age in patients with abnormal URINARY NAG was significantly different with mean age in patients normal URINARY NAG (p<0.001). There was a significant correlation between mean desferal usage duration in patients with abnormal URINARY NAG and normal URINARY NAG (p<0.002). We also found a significant correlation between mean transfusion duration in patients with abnormal URINARY NAG and whom with normal URINARY NAG (p<0.001).Conclusion: Renal disorders is not rare in beta thalassemia and increase with age growth, increased duration of transfusion and desferal usage and also increased with high levels of blood sugar.

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APA: Copy

MOHKAM, M., NARIMAN, SH., SHAMSIAN, SH., GACHKAR, L., & ARZANIAN, M.T.. (2005). EVALUATION OF UNINARY N-ACETYL GLUCOSAMINIDASE AND ITS RELATED PRAMETERS IN PATIENTS WITH Β2-THALASSEMIA MAJOR, IN MOFID CHILDREN HOSPITAL, 1383. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 10(3 (45)), 177-181. SID. https://sid.ir/paper/18436/en

Vancouver: Copy

MOHKAM M., NARIMAN SH., SHAMSIAN SH., GACHKAR L., ARZANIAN M.T.. EVALUATION OF UNINARY N-ACETYL GLUCOSAMINIDASE AND ITS RELATED PRAMETERS IN PATIENTS WITH Β2-THALASSEMIA MAJOR, IN MOFID CHILDREN HOSPITAL, 1383. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2005;10(3 (45)):177-181. Available from: https://sid.ir/paper/18436/en

IEEE: Copy

M. MOHKAM, SH. NARIMAN, SH. SHAMSIAN, L. GACHKAR, and M.T. ARZANIAN, “EVALUATION OF UNINARY N-ACETYL GLUCOSAMINIDASE AND ITS RELATED PRAMETERS IN PATIENTS WITH Β2-THALASSEMIA MAJOR, IN MOFID CHILDREN HOSPITAL, 1383,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 10, no. 3 (45), pp. 177–181, 2005, [Online]. Available: https://sid.ir/paper/18436/en

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