EFFICACY OF ORAL NALTREXONE IN TREATMENT OF PRURITUS IN PATIENTS WITH ECZEMA

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MALEKZAD F.; ARBABI MOHAMMAD; TOUSI PARVIZ; MOHTASHAM N.; MOHAJER M.; JABERIAN M.

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Journal: Researcher Bulletin of Medical Sciences Year:2007 | Volume:12 | Issue:4 (58) Page(s): 293-297

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Title

EFFICACY OF ORAL NALTREXONE IN TREATMENT OF PRURITUS IN PATIENTS WITH ECZEMA

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Keywords

NALTREXONEQ3

ECZEMAQ2

PRURITUSQ2

Abstract

Background: Regarding to the role of opioid receptors in peripheral cutaneous sensations and central itch procession, this study was designed to determine the efficacy of oral NALTREXONE in the treatment of PRURITUS in patients with ECZEMA in comparison with placebo.Materials and Methods: Thirty eight patients with ECZEMA complaining of PRURITUS were studied. PRURITUS scores were evaluated. Patients were given the placebo (n=20) or Nalterxone 50 mg (n=18) for a two-week period. During the study, PRURITUS scores were distinguished by a visual analogue scale (VAS) system and recorded in patients questionnaires three times, at the start of study, after 1 week, and after 2 weeks.Results: In the both groups VAS score were decreased, although Naltrexon was more effective than placebo in decreasing the VAS scores, both in 1st week week (P < 0.005) and 2nd week (P< 0.001). Adverse events (mainly nausea and sedation were observed in 3 patients (2 in Naltrexon group and I in placebo group).Conclusion: NALTREXONE is more effective than placebo in treatment of PRURITUS in patient affected with ECZEMA. NALTREXONE might be considered as an adjuvant remedy in treatment of PRURITUS.

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APA: Copy

MALEKZAD, F., ARBABI, MOHAMMAD, TOUSI, PARVIZ, MOHTASHAM, N., MOHAJER, M., & JABERIAN, M.. (2007). EFFICACY OF ORAL NALTREXONE IN TREATMENT OF PRURITUS IN PATIENTS WITH ECZEMA. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 12(4 (58)), 293-297. SID. https://sid.ir/paper/18552/en

Vancouver: Copy

MALEKZAD F., ARBABI MOHAMMAD, TOUSI PARVIZ, MOHTASHAM N., MOHAJER M., JABERIAN M.. EFFICACY OF ORAL NALTREXONE IN TREATMENT OF PRURITUS IN PATIENTS WITH ECZEMA. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2007;12(4 (58)):293-297. Available from: https://sid.ir/paper/18552/en

IEEE: Copy

F. MALEKZAD, MOHAMMAD ARBABI, PARVIZ TOUSI, N. MOHTASHAM, M. MOHAJER, and M. JABERIAN, “EFFICACY OF ORAL NALTREXONE IN TREATMENT OF PRURITUS IN PATIENTS WITH ECZEMA,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 12, no. 4 (58), pp. 293–297, 2007, [Online]. Available: https://sid.ir/paper/18552/en

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