مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Effect of High-intensity Interval Training and Moderate-intensity Continuous Training on miR-34a and PPARα Expression in Non-alcoholic Fatty Liver Disease Mice

Author(s)

 Foroughi Rahaghi Masoumeh Sadat | Moradi Lida | Abedi Bahram | Azarbaijani Mohammad Ali | Issue Writer Certificate 

Pages

  41-54

Abstract

 Background and Aim: Non-alcoholic fatty liver disease is one of the most common metabolic disorders associated with a high-fat diet. The miR-34a and PPARα genes play an important role in regulating lipids and hepatic inflammation. The present experimental study investigated the effect of high-intensity interval training and moderate-intensity continuous training on the expression of miR-34a and PPARα genes in male mice with non-alcoholic fatty liver disease induced by a high-fat diet. Materials and Methods: The statistical population of the present study consisted of C57BL/6J male mice. A total of 36 male mice, weighing 21-23 grams and aged 6-8 weeks, were purchased from the Pasteur Institute of Tehran, Iran. They were subsequently housed at Pasargad Tissue and Gene Technologists Knowledge-Based Company (Histogenotech) throughout the experimental period. After a two-week acclimatization period to the new environment and familiarization with the intervention protocol, the mice were randomly divided into 6 groups (n=6 rats per group): 1) normal-fat diet (NFD; control) , 2) normal-fat diet with high-intensity interval training (NFDHIIT), 3) normal-fat diet with moderate-intensity continuous training (NFDMICT), 4) high-fat diet (HFD), 5) high-fat diet with high-intensity interval training (HFDHIIT), 6) high-fat diet with moderate-intensity continuous training (HFDMICT). Mice in the NFDHIIT, NFDMICT, HFDHIIT, and HFDMICT groups underwent 8 weeks of treadmill training after 12 weeks of either HFD or normal diet feeding. The real-time PCR technique was used to examine the expression of miR-34a and PPARα genes in each group. Results: The expression of miR-34a and PPARα genes significantly increased in the HFD group compared to the NFD group (P<0.001). It was also observed that miR-34a gene expression significantly decreased in the HFDHIIT (P<0.001) and HFDMICT (P<0.05) groups compared to the HFD group, with more pronounced changes in the HIIT group. Meanwhile, the expression of PPARα significantly increased in the HFDHIIT (P<0.001) and HFDMICT (P<0.001) groups compared to the HFD group, with a greater increase observed in the HIIT group. Conclusion: In general, it can be concluded that exercise has an effective therapeutic role in improving liver condition and related metabolic indices, and this effect varies depending on the type and intensity of the exercise.

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