PROGNOSTIC SIGNIFICANCE OF HER-2 ONCOPROTEIN IN PREMENOPAUSAL NODE POSITIVE BREAST CANCER

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MORTAZAVI S.H.; AZADEH P.; VALAEI NASER

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Journal: Researcher Bulletin of Medical Sciences Year:2003 | Volume:8 | Issue:1 (31) Page(s): 7-13

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Title

PROGNOSTIC SIGNIFICANCE OF HER-2 ONCOPROTEIN IN PREMENOPAUSAL NODE POSITIVE BREAST CANCER

Author(s)

MORTAZAVI S.H. | AZADEH P. | VALAEI NASER | Issue Writer Certificate

Keywords

BREAST CANCERQ2

HER-2 ONCOPREOTEINQ3

ADJUVANT THERAPYQ4

Abstract

Background: The influence of HER-2 on prognosis of BREAST CANCER is a matter of controversy. The purpose of this study was to investigate the long-term prognostic significance of HER-2 oncoprotein expression in BREAST CANCER. Material and methods: 103 premenopausal node positive BREAST CANCER patients who received adjuvant treatment between 1004 and 1997 were enrolled in this study. The immunostaining for HER-2 was performed on formaldehyde solution fixed paraffin embedded sections of patients. HER-2 positive subjects were considered as the case group, whereas those negative for HER-2 compromised the control group. Prognosis was determined according to the overall survival (OS) and disease free surveillance (DFS). Results: Groups were similar according to the age, pathology, stage of the disease, type of surgery, and adjuvant. 30 patients (29.3%) revealed a positive staining for HER-2 oncoprotein. Positive staining correlated with absence of estrogen receptor content (P<0.009). The difference in survival between two groups was significant for overall and disease free survival (P<0.004). HER-2 positive patients who underwent oophorectomy revealed better HER-2 negative patients. In a multivariate analysis, HER-2 expression was an independent prognostic factor. Conclusion: This study supports the association of HER-2 oncoprotein expression with poor prognosis in node-positive premenopausal BREAST CANCER. Oopherrctomy must be considered as an adjuvant treatment for HER 2+patients. Further multicentric studies would precisely clarify the association.

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ارتباط ژن های HER2/neu و p53 و گیرنده های استروژن و پروژسترون با میزان بقا در زنان ایرانی مبتلا به سرطان پستان

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APA: Copy

MORTAZAVI, S.H., AZADEH, P., & VALAEI, NASER. (2003). PROGNOSTIC SIGNIFICANCE OF HER-2 ONCOPROTEIN IN PREMENOPAUSAL NODE POSITIVE BREAST CANCER. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 8(1 (31)), 7-13. SID. https://sid.ir/paper/18583/en

Vancouver: Copy

MORTAZAVI S.H., AZADEH P., VALAEI NASER. PROGNOSTIC SIGNIFICANCE OF HER-2 ONCOPROTEIN IN PREMENOPAUSAL NODE POSITIVE BREAST CANCER. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2003;8(1 (31)):7-13. Available from: https://sid.ir/paper/18583/en

IEEE: Copy

S.H. MORTAZAVI, P. AZADEH, and NASER VALAEI, “PROGNOSTIC SIGNIFICANCE OF HER-2 ONCOPROTEIN IN PREMENOPAUSAL NODE POSITIVE BREAST CANCER,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 8, no. 1 (31), pp. 7–13, 2003, [Online]. Available: https://sid.ir/paper/18583/en

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