PREDNISOLONE THERAPY IN REFRACTORY CHILDHOOD EPILEPSY

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MAHVELATI SHAMSABADI F.; AMINZADEH V.; GHOFRANI M.

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Journal: Researcher Bulletin of Medical Sciences Year:2007 | Volume:12 | Issue:2 (56) Page(s): 101-105

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Information Journal Paper

Title

PREDNISOLONE THERAPY IN REFRACTORY CHILDHOOD EPILEPSY

Author(s)

MAHVELATI SHAMSABADI F. | AMINZADEH V. | | GHOFRANI M. | Issue Writer Certificate

Keywords

PREDNISONEQ3

REFRACTORY EPILEPSYQ3

ADD ON THERAPYQ4

Abstract

Background: Steroids are effective medications for controlling the infantile spasms, but there have been few reports of steroid effect in other childhood epileptic syndromes, especially refractory syndromes. The objective of this study was to determine the efficacy of prednisolone in 35 children with intractable epilepsy. Materials and Methods: This prospective, uncontrolled study was undertaken at the Mofid pediatric Hospital from September 2004 to September 2005. Thirty five children (12 girls & 23 boys), aged between 1 to 12 years old with intractable epilepsy were enrolled. Prednisolone (1 mg/kg/day) was prescribed for 12 weeks (Once a day for 6 weeks followed by every other day for another 6 weeks) in addition to their regular antiepileptic medications. The parents kept seizure diaries. Results: after 1 year of follow up, 17 patients (49%) became seizure-free on prednisolone, whereas another 8 (23%) experienced a significant decreases more than 50% in seizure frequency. In contrast, ten patients (28%) had no changes in seizure frequency. The best response was seen in idiopathic epilepsy (95%) and atypical absence ones (86%). The least therapeutic effect was seen in symptomatic myoclonic epilepsy (54%). Side effects such as behavioral disturbances, weight gain and gastrointestinal bleeding were developed in 8 patients and also 14 patients were found to have cushingoid face. All the side effects were regressed after drug discontinuation. Conclusion: Prednisolone therapy is a safe and effective adjunctive treatment for children with intractable epilepsy and it should be considered as an alternative treatment for older children with REFRACTORY EPILEPSY.

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APA: Copy

MAHVELATI SHAMSABADI, F., AMINZADEH, V., & GHOFRANI, M.. (2007). PREDNISOLONE THERAPY IN REFRACTORY CHILDHOOD EPILEPSY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 12(2 (56)), 101-105. SID. https://sid.ir/paper/18587/en

Vancouver: Copy

MAHVELATI SHAMSABADI F., AMINZADEH V., GHOFRANI M.. PREDNISOLONE THERAPY IN REFRACTORY CHILDHOOD EPILEPSY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2007;12(2 (56)):101-105. Available from: https://sid.ir/paper/18587/en

IEEE: Copy

F. MAHVELATI SHAMSABADI, V. AMINZADEH, and M. GHOFRANI, “PREDNISOLONE THERAPY IN REFRACTORY CHILDHOOD EPILEPSY,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 12, no. 2 (56), pp. 101–105, 2007, [Online]. Available: https://sid.ir/paper/18587/en

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