ASSESSMENT OF DEMOGRAPHIC, CLINICAL AND LABORATORY STATUS OF PATIENTS WITH THALASSEMIA MAJOR AND INTERMEDIA REFERRED TO THALASSEMIA RESEARCH CENTER IN SARI, IRAN, DURING 2007-2009

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KARAMI HOSSEIN; KOUSARIAN M.; VAHIDSHAHI K.; KARAMI HASAN; SHAHMOHAMMADI S.; MAHDAVI MOHAMMAD REZA; HASHEMI M.B.; YOUSEFI ABDALMALEKI E.; MAJDI MOTAHAREH; AHANGARI M.

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Journal: Researcher Bulletin of Medical Sciences Year:2010 | Volume:15 | Issue:4 (76) Page(s): 186-192

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Title

ASSESSMENT OF DEMOGRAPHIC, CLINICAL AND LABORATORY STATUS OF PATIENTS WITH THALASSEMIA MAJOR AND INTERMEDIA REFERRED TO THALASSEMIA RESEARCH CENTER IN SARI, IRAN, DURING 2007-2009

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Keywords

BETA-THALASSEMIAQ2

THALASSEMIA MAJORQ3

THALASSEMIA INTERMEDIAQ3

GENETIC TESTINGQ3

MAZANDARANQ2

IRANQ2

Abstract

Background and Aim: MAZANDARAN province has the highest patient population ratio for THALASSEMIA MAJOR in the country (1 to 1000) and 11% of people living in MAZANDARAN province carry the disease gene. This study was performed to identify the clinical and laboratory status of the thalassemia patients referred to the largest therapeutic center of MAZANDARAN province.Materials and Methods: This cross sectional study was performed by reviewing of the patients' documents from May 2007 until May 2009. Demographic and clinical characteristics were extracted and analyzed by SPSS11, using descriptive statistics.Results: From 1010 patients' records, 53% were male. 84.2% of patients had THALASSEMIA MAJOR and 15.8% had THALASSEMIA INTERMEDIA. Mean age of patients was 23±8 years. 93 patients were married and 60 had children. The average of three last ferritin measurements was 1000-2000 in about 40% of the patients, 22% patients had ferritin level more than 3000. Cardiac MRI T2 was performed in 160 patients and 34% had severe iron storage. 81 patients (8%) had diabetes mellitus and age of diagnosis was 20±7 years. 28 patients were treated for heart failure. Hepatitis C infection occurred in 73 patients. Each month, 23,000 deferoxamine vial and 12,000 deferiprone tablets were used. Thirty patients received free Osveral. Conclusion: The age distribution of the patients indicates that prenatal screening has been successful. On the other hand, increased life expectancy of patients was due to medical care. Most of the patients are continuing their physical growth. So their need for blood and iron chalator drugs is increasing in following years.

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APA: Copy

KARAMI, HOSSEIN, KOUSARIAN, M., VAHIDSHAHI, K., KARAMI, HASAN, SHAHMOHAMMADI, S., MAHDAVI, MOHAMMAD REZA, HASHEMI, M.B., YOUSEFI ABDALMALEKI, E., MAJDI, MOTAHAREH, & AHANGARI, M.. (2010). ASSESSMENT OF DEMOGRAPHIC, CLINICAL AND LABORATORY STATUS OF PATIENTS WITH THALASSEMIA MAJOR AND INTERMEDIA REFERRED TO THALASSEMIA RESEARCH CENTER IN SARI, IRAN, DURING 2007-2009. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 15(4 (76)), 186-192. SID. https://sid.ir/paper/18651/en

Vancouver: Copy

KARAMI HOSSEIN, KOUSARIAN M., VAHIDSHAHI K., KARAMI HASAN, SHAHMOHAMMADI S., MAHDAVI MOHAMMAD REZA, HASHEMI M.B., YOUSEFI ABDALMALEKI E., MAJDI MOTAHAREH, AHANGARI M.. ASSESSMENT OF DEMOGRAPHIC, CLINICAL AND LABORATORY STATUS OF PATIENTS WITH THALASSEMIA MAJOR AND INTERMEDIA REFERRED TO THALASSEMIA RESEARCH CENTER IN SARI, IRAN, DURING 2007-2009. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2010;15(4 (76)):186-192. Available from: https://sid.ir/paper/18651/en

IEEE: Copy

HOSSEIN KARAMI, M. KOUSARIAN, K. VAHIDSHAHI, HASAN KARAMI, S. SHAHMOHAMMADI, MOHAMMAD REZA MAHDAVI, M.B. HASHEMI, E. YOUSEFI ABDALMALEKI, MOTAHAREH MAJDI, and M. AHANGARI, “ASSESSMENT OF DEMOGRAPHIC, CLINICAL AND LABORATORY STATUS OF PATIENTS WITH THALASSEMIA MAJOR AND INTERMEDIA REFERRED TO THALASSEMIA RESEARCH CENTER IN SARI, IRAN, DURING 2007-2009,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 15, no. 4 (76), pp. 186–192, 2010, [Online]. Available: https://sid.ir/paper/18651/en

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