ASSESSMENT OF THE EFFECT OF COMBINATION THERAPY WITH DEFERIPRONE & DESFERRIOXAMINE ON CARDIAC COMPLICATIONS IN MAJOR THALASSEMIA

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RASHIDI GHADER F.; KOUSARIAN M.; KARAMI HOSSEIN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:17 | Issue:61 Page(s): 12-19

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Title

ASSESSMENT OF THE EFFECT OF COMBINATION THERAPY WITH DEFERIPRONE & DESFERRIOXAMINE ON CARDIAC COMPLICATIONS IN MAJOR THALASSEMIA

Author(s)

RASHIDI GHADER F. | KOUSARIAN M. | KARAMI HOSSEIN | Issue Writer Certificate

Keywords

THALASSEMIAQ3

DEFERIPRONEQ3

DESFERRIOXAMINEQ3

CARDIAC DYSFUNCTIONQ3

Abstract

Background and Purpose: Cardiac complications in major thalassernia are the most debilitating problem among them. Iron chelating with DESFERRIOXAMINE, may be difficult or inadequate. The aim of this research is to evaluate the effect of combination therapy with the two drugs "deferiprone & DESFERRIOXAMINE" on cardiac complications in major thalassernia.Materials and Methods: In a clinical trial study (before & after), 47(24men and 23 women) patients with major THALASSEMIA referred to Booali research center, 10 to 35 years old, all of whom were undertaken combination therapy with DEFERIPRONE & DESFERRIOXAMINE, enrolled in this study.Echocardiography was performed for all patients before & after at least 6 months of combination therapy. Echocardiographic systolic & diastolic function indices including LVEF, EPSS, CI&E/A, EF slope & MPI, as well as presence of arrhythmia were obtained. The data were analyzed by paired T Test & Pearson correlation.Results: There were significant changes in ferritin, systolic function& MPI, indicating statistically significant improvement. Ferritin decreased to 3306±1347 ng/ml from 4489±1607 ng/ml (p=0.0001). VEF increased to 69.7±2.6% from 67.6±3.9% (p=0.04). EPSS decreased to 2.9±1.3mm from 3.9±2.lmm (p=0.004). Cardiac Index increased to 3.6±0.18 from 3.5±0.3 (p=0.02). MPI decreased to 0.33±0.05 from 0.37±0.06 (p=0.03). Arrhythmia & diastolic function were also slightly improved which were statistically no significant.Conclusion: The results showed that combination therapy with the two drugs DEFERIPRONE & DESFERRIOXAMINE led to decrease ferritin level and improve systolic function in patients with major THALASSEMIA.

Cites

ASSESSMENT OF DEMOGRAPHIC, CLINICAL AND LABORATORY STATUS OF PATIENTS WITH THALASSEMIA MAJOR AND INTERMEDIA REFERRED TO THALASSEMIA RESEARCH CENTER IN SARI, IRAN, DURING 2007-2009

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APA: Copy

RASHIDI GHADER, F., KOUSARIAN, M., & KARAMI, HOSSEIN. (2008). ASSESSMENT OF THE EFFECT OF COMBINATION THERAPY WITH DEFERIPRONE & DESFERRIOXAMINE ON CARDIAC COMPLICATIONS IN MAJOR THALASSEMIA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 17(61), 12-19. SID. https://sid.ir/paper/45899/en

Vancouver: Copy

RASHIDI GHADER F., KOUSARIAN M., KARAMI HOSSEIN. ASSESSMENT OF THE EFFECT OF COMBINATION THERAPY WITH DEFERIPRONE & DESFERRIOXAMINE ON CARDIAC COMPLICATIONS IN MAJOR THALASSEMIA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;17(61):12-19. Available from: https://sid.ir/paper/45899/en

IEEE: Copy

F. RASHIDI GHADER, M. KOUSARIAN, and HOSSEIN KARAMI, “ASSESSMENT OF THE EFFECT OF COMBINATION THERAPY WITH DEFERIPRONE & DESFERRIOXAMINE ON CARDIAC COMPLICATIONS IN MAJOR THALASSEMIA,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 61, pp. 12–19, 2008, [Online]. Available: https://sid.ir/paper/45899/en

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