EVALUATION OF OXIDATIVE STRESS BIOMARKERS AND ACETYLCHOLINESTERASE ACTIVITY IN GAMMARUS PSEUDOSYRIACUS EXPOSED TO NANOSILVER

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SHIRVANI FATEMEH; ARABI MEHRAN; NOORI DIZICHE ALI

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Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2013 | Volume:2 | Issue:1 Page(s): 39-44

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Title

EVALUATION OF OXIDATIVE STRESS BIOMARKERS AND ACETYLCHOLINESTERASE ACTIVITY IN GAMMARUS PSEUDOSYRIACUS EXPOSED TO NANOSILVER

Author(s)

SHIRVANI FATEMEH | ARABI MEHRAN | NOORI DIZICHE ALI | Issue Writer Certificate

Keywords

NANOSILVERQ1

GAMMARUSQ1

OXIDATIVE STRESSQ1

ACHEQ1

LIPID PEROXIDATIONQ2

Abstract

The extensive use of nanoparticles in a variety of applications has raised great concerns regarding their biological effects and environmental fate. Silver nanoparticle, often referred to as NANOSILVER (n-Ag), may cause health problems because of its wide and ever growing use in many applications. n-Ag is used in treatments of wounds, disinfection of water and/or air and coatings textiles. n-Ag is shows toxic effects only when oxidized to silver ions (Ag+). There is a limited knowledge concerning environmental and health consequences of exposure to n-Ag. In the current study, we aimed to evaluate the potential ecotoxicity of n-Ag for freshwater crustacean model organism, GAMMARUS pseudosyriacus.Three low concentration solutions of n-Ag (2.5, 5 and 7.5 ppm) were used over a period of 96 hr. The concentrations of n-Ag used in this study are not environmentally relevant but provide a model system to examine its ecotoxicity.It was revealed that n-Ag imposes a severe LIPID PEROXIDATION (LPO/MDA) in GAMMARUS whole body extract. In addition, the activity of some antioxidant enzymes changed. Catalase (CAT) activity was decreased and glutathione peroxidase (GPx) activity significantly increased. Acetylcholinesterase (AChE) activity was also markedly decreased. An abnormal vigorous movement was observed among animals.Briefly, n-Ag was found highly toxic to aquatic organisms and has the potential to exert a strong OXIDATIVE STRESS, leading to altered physiological state.

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APA: Copy

SHIRVANI, FATEMEH, ARABI, MEHRAN, & NOORI DIZICHE, ALI. (2013). EVALUATION OF OXIDATIVE STRESS BIOMARKERS AND ACETYLCHOLINESTERASE ACTIVITY IN GAMMARUS PSEUDOSYRIACUS EXPOSED TO NANOSILVER. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 2(1), 39-44. SID. https://sid.ir/paper/188729/en

Vancouver: Copy

SHIRVANI FATEMEH, ARABI MEHRAN, NOORI DIZICHE ALI. EVALUATION OF OXIDATIVE STRESS BIOMARKERS AND ACETYLCHOLINESTERASE ACTIVITY IN GAMMARUS PSEUDOSYRIACUS EXPOSED TO NANOSILVER. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2013;2(1):39-44. Available from: https://sid.ir/paper/188729/en

IEEE: Copy

FATEMEH SHIRVANI, MEHRAN ARABI, and ALI NOORI DIZICHE, “EVALUATION OF OXIDATIVE STRESS BIOMARKERS AND ACETYLCHOLINESTERASE ACTIVITY IN GAMMARUS PSEUDOSYRIACUS EXPOSED TO NANOSILVER,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 2, no. 1, pp. 39–44, 2013, [Online]. Available: https://sid.ir/paper/188729/en

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