CYTOTOXICITY ASSESSMENT OF NANOLIPOSOMAL PACLITAXEL AND NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELLS

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MOVAHEDI FATEMEH; KOOHI MOFTAKHARI ESFAHANI MAEDEH; ALAVI SEYED EBRAHIM; AKBARZADEH AZIM

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Journal Paper

Paper Information

Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2013 | Volume:2 | Issue:1 Page(s): 15-17

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Title

CYTOTOXICITY ASSESSMENT OF NANOLIPOSOMAL PACLITAXEL AND NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELLS

Author(s)

MOVAHEDI FATEMEH | KOOHI MOFTAKHARI ESFAHANI MAEDEH | ALAVI SEYED EBRAHIM | AKBARZADEH AZIM | Issue Writer Certificate

Keywords

NANOTECHNOLOGYQ1

BREAST CANCERQ2

PACLITAXELQ1

HYDROXYUREAQ1

LIPOSOMEQ1

CYTOTOXICITYQ1

Abstract

NANOTECHNOLOGY has revolutionized diagnosis and treatment of cancers. BREAST CANCER is one of the most prevalent cancers among women. PACLITAXEL and HYDROXYUREA are important drugs in treatment of BREAST CANCER but their use is limited due to a series of significant side effects. On the other hand, nanoliposomes are widely used as nanocarriers for targeted drug delivery. In this study, cytotoxic effects of nanoliposomal HYDROXYUREA and nanoliposomal PACLITAXEL were investigated. LIPOSOMEs were prepared using reversed phase evaporation. CYTOTOXICITY of liposomal formulations of the drugs was determined using Methylthiazolyldiphenyl-tetrazolium bromide (MTT) method. Results showed an IC50 level of 86.25 ml/ml for nanoliposomal HYDROXYUREAand and 43.78 ml/ml for nanoliposomal PACLITAXEL. In general, it can be concluded that that CYTOTOXICITY of nanoliposomal drugs are higher than that of standard formulations.

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References

RECEPTOR MEDIATED TUMOR TARGETING: AN EMERGING APPROACH FOR CANCER THERAPY

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APA: Copy

MOVAHEDI, FATEMEH, KOOHI MOFTAKHARI ESFAHANI, MAEDEH, ALAVI, SEYED EBRAHIM, & AKBARZADEH, AZIM. (2013). CYTOTOXICITY ASSESSMENT OF NANOLIPOSOMAL PACLITAXEL AND NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELLS. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 2(1), 15-17. SID. https://sid.ir/paper/188732/en

Vancouver: Copy

MOVAHEDI FATEMEH, KOOHI MOFTAKHARI ESFAHANI MAEDEH, ALAVI SEYED EBRAHIM, AKBARZADEH AZIM. CYTOTOXICITY ASSESSMENT OF NANOLIPOSOMAL PACLITAXEL AND NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELLS. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2013;2(1):15-17. Available from: https://sid.ir/paper/188732/en

IEEE: Copy

FATEMEH MOVAHEDI, MAEDEH KOOHI MOFTAKHARI ESFAHANI, SEYED EBRAHIM ALAVI, and AZIM AKBARZADEH, “CYTOTOXICITY ASSESSMENT OF NANOLIPOSOMAL PACLITAXEL AND NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELLS,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 2, no. 1, pp. 15–17, 2013, [Online]. Available: https://sid.ir/paper/188732/en

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