TOTAL PHENOL AND FLAVONOID CONTENTS OF MERISTOTROPIS XANTHIOIDES VASSILCZ. SPECIES EXTRACT AND ITS PROTECTIVE EFFECT ON ETHANOL-INDUCED HEPATOTOXICITY

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YARI S.; KARAMIAN R.; ASADBEGY M.

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Journal: JOURNAL OF CELL & TISSUE Year:2016 | Volume:7 | Issue:3 Page(s): 323-332

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Information Journal Paper

Title

TOTAL PHENOL AND FLAVONOID CONTENTS OF MERISTOTROPIS XANTHIOIDES VASSILCZ. SPECIES EXTRACT AND ITS PROTECTIVE EFFECT ON ETHANOL-INDUCED HEPATOTOXICITY

Author(s)

YARI S. | KARAMIAN R. | ASADBEGY M. | Issue Writer Certificate

Keywords

MERISTOTROPIS XANTHIOIDESQ1

PHENOLQ1

HEPATOTOXICITYQ2

ETHANOLQ1

ANTIOXIDANTQ2

Abstract

Aim: The aim of this study was to assess the protective effect of MERISTOTROPIS XANTHIOIDES extract on ETHANOL-induced HEPATOTOXICITY.Material and methods: The total PHENOL and flavonoid contents of the species were measured by Folin Ciocalteu and AlCl3, respectively. Male Wistar rats were divided into three groups: group 1 (control), group 2: received 1ml 50 % ETHANOL, group 3: received 1ml ETHANOL (50 %) plus the extract (500 mg/kg), each group consisted of six rats. All treatments were performed by intragastric administration. Silymarin was used as positive control. Biochemical, histological and morphological analyses were used for evaluation of HEPATOTOXICITY.Results: The extract had high total PHENOLic and flavonoid contents. Alcohol consumption significantly increased liver/body weight ratio, amounts of tissue’s malondialdehyde (MDA), H2O2 and also liver enzymes in blood in comparison to other groups. Histological examination showed that alcohol consumption injures liver tissue intensely. All these alcohol-induced changes were effectively inhibited by treatment with the extract.Conclusion: This research confirmed that the species can represent the protective role on ETHANOLinduced HEPATOTOXICITY and suggested its capacity to apply as a new healthcare food and drug supplement.

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APA: Copy

YARI, S., KARAMIAN, R., & ASADBEGY, M.. (2016). TOTAL PHENOL AND FLAVONOID CONTENTS OF MERISTOTROPIS XANTHIOIDES VASSILCZ. SPECIES EXTRACT AND ITS PROTECTIVE EFFECT ON ETHANOL-INDUCED HEPATOTOXICITY. JOURNAL OF CELL & TISSUE, 7(3 ), 323-332. SID. https://sid.ir/paper/188892/en

Vancouver: Copy

YARI S., KARAMIAN R., ASADBEGY M.. TOTAL PHENOL AND FLAVONOID CONTENTS OF MERISTOTROPIS XANTHIOIDES VASSILCZ. SPECIES EXTRACT AND ITS PROTECTIVE EFFECT ON ETHANOL-INDUCED HEPATOTOXICITY. JOURNAL OF CELL & TISSUE[Internet]. 2016;7(3 ):323-332. Available from: https://sid.ir/paper/188892/en

IEEE: Copy

S. YARI, R. KARAMIAN, and M. ASADBEGY, “TOTAL PHENOL AND FLAVONOID CONTENTS OF MERISTOTROPIS XANTHIOIDES VASSILCZ. SPECIES EXTRACT AND ITS PROTECTIVE EFFECT ON ETHANOL-INDUCED HEPATOTOXICITY,” JOURNAL OF CELL & TISSUE, vol. 7, no. 3 , pp. 323–332, 2016, [Online]. Available: https://sid.ir/paper/188892/en

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