Antioxidant Activity of Glycyrrhiza glabra L. Extract and Protective Effect of its Leaf Extract on Ethanol-Induced Nephrotoxicity in Male Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARAMIAN R.; Asad beigy M.; YARI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:26 | Issue:4 Page(s): 1-12

Download Full-Text

Persian Verion

View:

448

Download:

Cites:

Information Journal Paper

Title

Antioxidant Activity of Glycyrrhiza glabra L. Extract and Protective Effect of its Leaf Extract on Ethanol-Induced Nephrotoxicity in Male Rats

Author(s)

KARAMIAN R. | Asad beigy M. | YARI S. | Issue Writer Certificate

Keywords

Glycyrrhiza glabra L.Q1

Antioxidant activityQ1

EthanolQ1

NephrotoxicityQ1

PhenolQ1

RatsQ1

Abstract

Introduction: Acute alcohol consumption leads to induction of lipid peroxidation in renal tissues, but its chronic consumption has moderate effects on biochemical and histological characteristics of this organ. Antioxidants have protective effects against Ethanol-induced oxidative stress and tissue injury. The aim of this study was to assess Antioxidant activity of Glycyrrhiza glabra L.af and stem extracts and the protective effect of its leaf extract on Ethanol-induced Nephrotoxicity. Materials & methods: Total Phenol and flavonoid contents of leaf and stem extracts of G. glabra were measured by Folin Ciocalteu and AlCl3 assays, respectively. Antioxidant activity of both extracts was assessed using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging. In addition, protective effect of the leaf extract was assessed using biochemical and histological analyses of renal tissues of male Wistar Rats, which were divided into four groups including group 1 or control (received 1 ml distilled water daily), group 2 or Ethanol group (received 1 ml of 50% Ethanol daily), group 3 or Ethanol + leaf extract group (received 1 ml of 50% Ethanol + 500 mg/kg leaf extract daily), and group 4 (received 500 mg/kg of leaf extract daily). All treatments are performed through intragastric administration. Biochemical and histological analyses were used for the evaluation of Nephrotoxicity. For histological study, the samples were stained with Hematoxylin-Eosin and examined by light microscopy. Finally, all the data were analyzed by SPSS (Ver. 20) and grouped by Duncan's Multiple Range Test at P <0. 05 level. Findings: There was no significant difference between total Phenol contents of the stem and leaf extracts. However, the stem extract showed a higher total flavonoid content than the leaf extract. Also, both the extracts showed higher antioxidant activities (86-93%) than that of ascorbic acid (71%). Results from biochemical analysis indicated a significant increase in superoxide dismutase (SOD) activity and H2O2 content in the renal tissues of Ethanol-treated Rats in comparison with other groups; however, there were no significant changes in total protein and malondialdehyde (MDA) contents. Results from histological examination showed that alcohol consumption intensity injured kidney tissues, which was effectively moderated by the studied extract. Discussion & Conclusions: Results from the present study showed that G. glabra extract has biological activity and can be used in future as a new natural antioxidant in food and drug industries.

Cites

No record.

References

No record.

Cite

APA: Copy

KARAMIAN, R., Asad beigy, M., & YARI, S.. (2018). Antioxidant Activity of Glycyrrhiza glabra L. Extract and Protective Effect of its Leaf Extract on Ethanol-Induced Nephrotoxicity in Male Rats. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(4 ), 1-12. SID. https://sid.ir/paper/90201/en

Vancouver: Copy

KARAMIAN R., Asad beigy M., YARI S.. Antioxidant Activity of Glycyrrhiza glabra L. Extract and Protective Effect of its Leaf Extract on Ethanol-Induced Nephrotoxicity in Male Rats. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(4 ):1-12. Available from: https://sid.ir/paper/90201/en

IEEE: Copy

R. KARAMIAN, M. Asad beigy, and S. YARI, “Antioxidant Activity of Glycyrrhiza glabra L. Extract and Protective Effect of its Leaf Extract on Ethanol-Induced Nephrotoxicity in Male Rats,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 4 , pp. 1–12, 2018, [Online]. Available: https://sid.ir/paper/90201/en

Related Journal Papers