THE EFFECT OF HONEY BEE VENOM AND ALL-TRANS RETINOIC ACID ON PROLIFERATION AND DIFFERENTIATION OF HL-60 CELL LINE

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PARIVAR K.; NABIUNI M.; JALALI H.; NADALI F.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2011 | Volume:10 | Issue:2 (39) Page(s): 112-126

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Title

THE EFFECT OF HONEY BEE VENOM AND ALL-TRANS RETINOIC ACID ON PROLIFERATION AND DIFFERENTIATION OF HL-60 CELL LINE

Author(s)

PARIVAR K. | NABIUNI M. | JALALI H. | NADALI F. | Issue Writer Certificate

Keywords

HONEY BEE VENOMQ2

HL-60 CELL LINEQ2

CELL PROLIFERATION AND DIFFERENTIATIONQ2

ALL-TRANS RETINOIC ACIDQ2

Abstract

Background and Objectives: Differentiation therapy is one of the methods for treatment of cancer. In this method, some drugs such as ALL-TRANS RETINOIC ACID, are used which can inhibit proliferation of cancerous cells and induce cell differentiation. Previus experiments showed some anti-proliferation materials, anti-inflammation materials or anti-oxidant materials could influence the effects of such drugs and decrease resulting side effects. In this research the effects of the HONEY BEE VENOM, on ALL-TRANS RETINOIC ACID functions was measured. Materials and Methods: In this experimental project we used HL-60 CELL LINE belonging to acute promyelocyte leukemia. The HL-60 CELL LINE was obtained from Pasteur Institute of Iran, and were grown in RPMI 1640 medium (Roswell Park Memorial Institute) containing 10% FBS (Fetal Bovine Serum) and 1% streptomycin penicilin. We used MTT (3- (4, 5-Dimethylthiazol-2-yl) -2, 5-Diphenyltetrazolium bromide) and NBT (Nitro-Blue tetrazolium chloride) tests for these purposes.All experiments were done three times and data were analyzed using SPSS.Results: Both HONEY BEE VENOM and ALL-TRANS RETINOIC ACID could inhibit proliferation of HL-60 cells, also ALL-TRANS RETINOIC ACID could induce differentiation in this cells. The amount of differentiation was increased significantly (p<0.01) in the presence of HONEY BEE VENOM.Conclusion: On the base of our findings, it seemed that HONEY BEE VENOM could increase anti cancer effects of ALL-TRANS RETINOIC ACID.

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APA: Copy

PARIVAR, K., NABIUNI, M., JALALI, H., & NADALI, F.. (2011). THE EFFECT OF HONEY BEE VENOM AND ALL-TRANS RETINOIC ACID ON PROLIFERATION AND DIFFERENTIATION OF HL-60 CELL LINE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 10(2 (39)), 112-126. SID. https://sid.ir/paper/71100/en

Vancouver: Copy

PARIVAR K., NABIUNI M., JALALI H., NADALI F.. THE EFFECT OF HONEY BEE VENOM AND ALL-TRANS RETINOIC ACID ON PROLIFERATION AND DIFFERENTIATION OF HL-60 CELL LINE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2011;10(2 (39)):112-126. Available from: https://sid.ir/paper/71100/en

IEEE: Copy

K. PARIVAR, M. NABIUNI, H. JALALI, and F. NADALI, “THE EFFECT OF HONEY BEE VENOM AND ALL-TRANS RETINOIC ACID ON PROLIFERATION AND DIFFERENTIATION OF HL-60 CELL LINE,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 10, no. 2 (39), pp. 112–126, 2011, [Online]. Available: https://sid.ir/paper/71100/en

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