The Effects of 8-Hydroxyquinoline-Coated Graphene Oxide on Cell Death and Apoptosis in Breast(MCF-7) and Colorectal(SW742) Cancer Cell Lines

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHEILTASH F.; PARIVAR K.; HAYATI ROODBARI N.; BADIEI A.; SADEGHI B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2019 | Volume:12 | Issue:2 (45) Page(s): 85-104

Download Full-Text

Persian Verion

View:

791

Download:

Cites:

Information Journal Paper

Title

The Effects of 8-Hydroxyquinoline-Coated Graphene Oxide on Cell Death and Apoptosis in Breast(MCF-7) and Colorectal(SW742) Cancer Cell Lines

Author(s)

Keywords

Graphene OxideQ1

8-HydroxyquinolineQ1

Breast CancerQ1

Colorectal CancerQ1

ApoptosisQ1

Abstract

Inroduction & Objective: Breast and Colorectal Cancers are of the major causes of cancer-related death worldwide. The anticancer properties of 8-Hydroxyquinoline (8HQ), and the increasing use of Graphene Oxide (GO) as a drug delivery system with anti-cancerous properties, led us to investigate toxicity and Apoptosis-induction capability of 8HQ-coated GO on breast and Colorectal Cancer cells compared to normal breast cells. Material and Method: The Breast Cancer (MCF-7), Colorectal Cancer (SW-742) and normal breast (MCF-10) cell lines were treated with several doses of 8-HQ-coated GO for 12, 24, and 48 hours. The toxicity of nanocomposite was measured using MTT assay and the effect of nanocomposite on cell Apoptosis were determined by examining the expression of P53, P21, Bax and Bcl-2 genes, as well as Annexin-V /PI Apoptosis assay. Results: There were significantly increased cell death in nanocomposite-treated colorectal and Breast Cancer cells, especially MCF-7, compared to treated normal breast cells. A significant increased expression of P53, P21 and Bax genes and reduced expression of Bcl-2 gene were found in both treated cancer cell lines compared to the normal breast cell line. Annexin-V/PI assay also illustrated a significant induction of Apoptosis in the cancerous cell lines, especially MCF-7, following nanocomposite treatment. Conclussion: Overall, 8HQ-coated GO has toxicity for breast and colorecctal cancer cell lines, and one of the mechanisms through which this nanocomposite can induce cell death is induction of Apoptosis. With complementary and in vivo studies, this nanocomposite can be suggested as a nano-drug with anti-cancer properties.

Cites

No record.

References

No record.

Cite

APA: Copy

KHEILTASH, F., PARIVAR, K., HAYATI ROODBARI, N., BADIEI, A., & SADEGHI, B.. (2019). The Effects of 8-Hydroxyquinoline-Coated Graphene Oxide on Cell Death and Apoptosis in Breast(MCF-7) and Colorectal(SW742) Cancer Cell Lines. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 12(2 (45) ), 85-104. SID. https://sid.ir/paper/191645/en

Vancouver: Copy

KHEILTASH F., PARIVAR K., HAYATI ROODBARI N., BADIEI A., SADEGHI B.. The Effects of 8-Hydroxyquinoline-Coated Graphene Oxide on Cell Death and Apoptosis in Breast(MCF-7) and Colorectal(SW742) Cancer Cell Lines. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2019;12(2 (45) ):85-104. Available from: https://sid.ir/paper/191645/en

IEEE: Copy

F. KHEILTASH, K. PARIVAR, N. HAYATI ROODBARI, A. BADIEI, and B. SADEGHI, “The Effects of 8-Hydroxyquinoline-Coated Graphene Oxide on Cell Death and Apoptosis in Breast(MCF-7) and Colorectal(SW742) Cancer Cell Lines,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 12, no. 2 (45) , pp. 85–104, 2019, [Online]. Available: https://sid.ir/paper/191645/en

Related Journal Papers