Evaluation of spinacetin 7-O-β-D-glucopyranoside in the induction of apoptosis in breast cancer cell line MCF-7

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AGHAEI M.; GHANADIAN S.M.; FALLAH M.; Solimani Dehkordi e.

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Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2018 | Volume:20 | Issue:4 Page(s): 25-32

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Title

Evaluation of spinacetin 7-O-β-D-glucopyranoside in the induction of apoptosis in breast cancer cell line MCF-7

Author(s)

AGHAEI M. | GHANADIAN S.M. | FALLAH M. | Solimani Dehkordi e. | Issue Writer Certificate

Keywords

FlavonoidsQ2

ApoptosisQ1

Breast cancerQ2

Cell cytotoxicitiesQ1

Abstract

Background and aims: This study was aimed to evaluate the effect of spinacetin 7-O-β-D-glucopyranoside, a flanovid compound separated from Centurea shmidi against MCF-7 Breast cancer cell line and its effect on Apoptosis induction. Methods: In this study, the inhibition rate of cell growth and induction of Apoptosis in MCF-7 cell culture cells after treatment with different concentrations of spinostine glycoside was studied by MTT and flow cytometry. Results: According to the results of MTT test, after 48 hours treatment with spinostin-7-O-β-D-glucoside, a significant inhibition in cell proliferation was observed compared to the control group (P <0. 05). The results of the study of Apoptosis in the flow cytometry assay showed that the derived flavonoid increased significantly the Apoptosis in MCF-7 Breast cancer cell line (P<0. 05). Conclusion: The derived flavonoid of spinacetin-7-O-β-D-glucopyranoside significantly inhibited MCF-7 proliferation and induced Apoptosis. So, it could be suggested as a compound for Breast cancer therapy.

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APA: Copy

AGHAEI, M., GHANADIAN, S.M., FALLAH, M., & Solimani Dehkordi, e.. (2018). Evaluation of spinacetin 7-O-β-D-glucopyranoside in the induction of apoptosis in breast cancer cell line MCF-7. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 20(4 ), 25-32. SID. https://sid.ir/paper/58134/en

Vancouver: Copy

AGHAEI M., GHANADIAN S.M., FALLAH M., Solimani Dehkordi e.. Evaluation of spinacetin 7-O-β-D-glucopyranoside in the induction of apoptosis in breast cancer cell line MCF-7. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(4 ):25-32. Available from: https://sid.ir/paper/58134/en

IEEE: Copy

M. AGHAEI, S.M. GHANADIAN, M. FALLAH, and e. Solimani Dehkordi, “Evaluation of spinacetin 7-O-β-D-glucopyranoside in the induction of apoptosis in breast cancer cell line MCF-7,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 4 , pp. 25–32, 2018, [Online]. Available: https://sid.ir/paper/58134/en

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