EVALUATION OF NECROTIC EFFECTS OF INTRAPERITONEAL ADMINISTRATION OF NANO-SILVE ON RAT HIPPOCAMPAL CELLS

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NASROLLAHZADE H.; KHODARAHMI P.; HEYDARI NASRABADI M.

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2015 | Volume:8 | Issue:1 (28) Page(s): 23-31

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Title

EVALUATION OF NECROTIC EFFECTS OF INTRAPERITONEAL ADMINISTRATION OF NANO-SILVE ON RAT HIPPOCAMPAL CELLS

Author(s)

NASROLLAHZADE H. | KHODARAHMI P. | HEYDARI NASRABADI M. | Issue Writer Certificate

Keywords

HIPPOCAMPUSQ2

NANO SILVERQ2

NECROSISQ2

NISSL STAININGQ2

Abstract

Inroduction & Objective: Silver nanoparticles are very promising engineered which play an important role in the world biomedical, healthcare and in general nanotechnology applications. In this study, the necrotic effects of short and long term administrations of nanosilver on rat HIPPOCAMPUS, which is involved in memory and learning, was investigated.Materials and Methods: 56 male Wistar rats were divided into two groups of short term and long term injections which were treated for 5 and 10 consecutive days, respectively. Each group was divided into four subgroups of control, 100, 200 and 400 ppm nanosilver administration. The control subgroup received saline and the treatment subgroups received intraperitoneal injections of silver nanoparticles at doses of 100, 200 and 400ppm. Ten days after the last injection, the hippocampal tissue sections were prepared and the extent of NECROSIS was evaluated stained with Nissl.Results: In short term (5-day injection) group, the percentage of necrotic cells between control and 100 (p<0.01), 200 and 400 ppm were significant (p<0.001), showing statistically significant difference between control and treatment subgroups. In long term (10-day injection) group, the percentage of necrotic cells between control and 200 and 400 ppm subgroups were significant (p<0.001), respectively, again representing statistically significant difference between control and treatment subgroups.Conclusion: Silver nanoparticles induce NECROSIS in rat hippocampal cells. For the administration regime considered in this study, this apoptotic effect increases at higher doses but is independent of the duration of exposure.

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APA: Copy

NASROLLAHZADE, H., KHODARAHMI, P., & HEYDARI NASRABADI, M.. (2015). EVALUATION OF NECROTIC EFFECTS OF INTRAPERITONEAL ADMINISTRATION OF NANO-SILVE ON RAT HIPPOCAMPAL CELLS. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 8(1 (28)), 23-31. SID. https://sid.ir/paper/191798/en

Vancouver: Copy

NASROLLAHZADE H., KHODARAHMI P., HEYDARI NASRABADI M.. EVALUATION OF NECROTIC EFFECTS OF INTRAPERITONEAL ADMINISTRATION OF NANO-SILVE ON RAT HIPPOCAMPAL CELLS. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2015;8(1 (28)):23-31. Available from: https://sid.ir/paper/191798/en

IEEE: Copy

H. NASROLLAHZADE, P. KHODARAHMI, and M. HEYDARI NASRABADI, “EVALUATION OF NECROTIC EFFECTS OF INTRAPERITONEAL ADMINISTRATION OF NANO-SILVE ON RAT HIPPOCAMPAL CELLS,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 8, no. 1 (28), pp. 23–31, 2015, [Online]. Available: https://sid.ir/paper/191798/en

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