The effect of chlordiazepoxide used during pregnancy on bad gene expression in the hippocampus of neonatal rats

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DINARVAND AMIN; HASHEMI MEHRDAD; Dinarvand Rasool; Movaseghi Shabnam; JAFARINIA MOJTABA

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2019 | Volume:11 | Issue:2 Page(s): 43-52

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Title

The effect of chlordiazepoxide used during pregnancy on bad gene expression in the hippocampus of neonatal rats

Author(s)

Keywords

Gene expressionQ1

ChlorodiazepoxideQ1

RatQ2

HippocampusQ2

bad geneQ1

Abstract

Chlorodiazepoxide is an anxiolytic agent commonly used by young people and pregnant women to reduce anxiety and control preeclampsia and eclampsia. Some studies have shown that this medication disrupts the functioning of the cholinergic system. Due to the increased cellular damage of bad Gene expression, the effect of cholorodiazepoxide used during pregnancy on bad Gene expression in the Hippocampus of neonatal Rats was investigated. In this study, 9 female Wistar Rats were pregnant and randomly divided into three groups: control, experimental (intraperitoneal injection of chlordiazoxoxide 10 mg / kg for 21 days) and carriers (saline). Two weeks after the birth, the brain of the neonates was removed from the skull and the expression of the propaoptotic gene of bad was investigated. The level of Gene expression was analyzed by Rest software and a significant level of P <0. 05 was considered. Propoptotic gene, bad showed significant increase in experimental group compared to control group. The results of this study indicated that the administRation of Chlorodiazepoxide during pregnancy can cause neuronal damage in the Hippocampus of Wistar Rats.

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APA: Copy

DINARVAND, AMIN, HASHEMI, MEHRDAD, Dinarvand, Rasool, Movaseghi, Shabnam, & JAFARINIA, MOJTABA. (2019). The effect of chlordiazepoxide used during pregnancy on bad gene expression in the hippocampus of neonatal rats. JOURNAL OF DEVELOPMENTAL BIOLOGY, 11(2 ), 43-52. SID. https://sid.ir/paper/193097/en

Vancouver: Copy

DINARVAND AMIN, HASHEMI MEHRDAD, Dinarvand Rasool, Movaseghi Shabnam, JAFARINIA MOJTABA. The effect of chlordiazepoxide used during pregnancy on bad gene expression in the hippocampus of neonatal rats. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2019;11(2 ):43-52. Available from: https://sid.ir/paper/193097/en

IEEE: Copy

AMIN DINARVAND, MEHRDAD HASHEMI, Rasool Dinarvand, Shabnam Movaseghi, and MOJTABA JAFARINIA, “The effect of chlordiazepoxide used during pregnancy on bad gene expression in the hippocampus of neonatal rats,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 11, no. 2 , pp. 43–52, 2019, [Online]. Available: https://sid.ir/paper/193097/en

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