Bad gene expression following effect of coenzyme Q10 on Wistar rat hippocampus with cerebral ischemia

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Kazemi Asafeh Farnoosh; ENTEZARI MALIHEH; Shirvani Shahenayati Maryam

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2020 | Volume:29 | Issue:4 Page(s): 296-302

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Title

Bad gene expression following effect of coenzyme Q10 on Wistar rat hippocampus with cerebral ischemia

Author(s)

Kazemi Asafeh Farnoosh | ENTEZARI MALIHEH | Shirvani Shahenayati Maryam | Issue Writer Certificate

Keywords

CoQ10Q2

ApoptosisQ2

HippocampusQ2

Real Time PCRQ2

Abstract

Background: Q10 coenzyme is a potent antioxidant in the mitochondrial membrane. Releasing the oxygen free radicals occurs in the cerebral ischemia. Using Q10 coenzyme causes strength against oxidative after injury of cerebral ischemia during reperfusion. Also CoQ10 plays an important anti-apoptotic role to reduce Caspase 3 as a key enzyme neuroprotective in Apoptosis. According to the sensitive nature of CA1-Hypocampus pyramidal neurons against the cerebral ischemia, we studied the effects of CoQ10 in this area of rat`s brain after transient general ischemia/ reperfusion. Materials and methods: We selected randomly 24 heads of Wistar rats under 250-300 g weights that divided into 4 groups, including control, experiment (ischemia, Q10), ischemia and Q10 coenzyme groups. Then we separated the Hippocampus from the brain expression of pro-Apoptosis genes was studied. After extraction of RNA and synthesis of cDNA, we used real time RCR methods to express this gene. Results: The expression of Bad gene in experiment group (Q10, 10mg/Kg) significantly decreased compared to ischemia group (p<0. 05). Conclusion: It seems that ischemia caused to increase the expression of Bad pro-apoptic gene, and CoQ10 with dose of 10mg/Kg has effects on the expression of Bad gene and prevent the severity of lesions.

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References

Coenzyme Q10 deficiencies: pathways in yeast and humans

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APA: Copy

Kazemi Asafeh, Farnoosh, ENTEZARI, MALIHEH, & Shirvani Shahenayati, Maryam. (2020). Bad gene expression following effect of coenzyme Q10 on Wistar rat hippocampus with cerebral ischemia. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 29(4 ), 296-302. SID. https://sid.ir/paper/98678/en

Vancouver: Copy

Kazemi Asafeh Farnoosh, ENTEZARI MALIHEH, Shirvani Shahenayati Maryam. Bad gene expression following effect of coenzyme Q10 on Wistar rat hippocampus with cerebral ischemia. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2020;29(4 ):296-302. Available from: https://sid.ir/paper/98678/en

IEEE: Copy

Farnoosh Kazemi Asafeh, MALIHEH ENTEZARI, and Maryam Shirvani Shahenayati, “Bad gene expression following effect of coenzyme Q10 on Wistar rat hippocampus with cerebral ischemia,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 29, no. 4 , pp. 296–302, 2020, [Online]. Available: https://sid.ir/paper/98678/en

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